Stopped at the border: boundaries and insulators

被引：176

作者：

Bell, AC ^{[1
]}

Felsenfeld, G ^{[1
]}

机构：

[1] NIDDKD, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(99)80029-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Boundaries in chromatin are often marked by the presence of insulator elements. New results in Drosophila have identified an insulator with a proven boundary function essential for development. Other studies suggest a connection between the activity of some insulators and Drosophila tritihorax-Group and Polycomb-Group genes. Several examples of vertebrate insulators have now been found; their locations suggest important boundary functions. Enhancer-blocking studies in oocytes and position-effect studies in transformed cells shed new light on insulator mechanisms.

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页码：191 / 198

页数：8

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