共 53 条
Aging-Related Neurostructural, Neuropathological, and Behavioral Changes Associated with Herpes Simplex Virus Type 1 Brain Infection in Mice
被引:20
作者:

Guzman-Sanchez, Fernando
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Autonoma Madrid, Dept Biol Mol, Ctr Biol Mol Severo Ochoa, Madrid, Spain
Consejo Super Invest Cient CBM UAM CSIC, Madrid, Spain Neuron Bio, BioPharma Div, Granada 18100, Spain

Valdivieso, Fernando
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Autonoma Madrid, Dept Biol Mol, Ctr Biol Mol Severo Ochoa, Madrid, Spain
Consejo Super Invest Cient CBM UAM CSIC, Madrid, Spain Neuron Bio, BioPharma Div, Granada 18100, Spain

Burgos, Javier S.
论文数: 0 引用数: 0
h-index: 0
机构:
Neuron Bio, BioPharma Div, Granada 18100, Spain Neuron Bio, BioPharma Div, Granada 18100, Spain
机构:
[1] Neuron Bio, BioPharma Div, Granada 18100, Spain
[2] Univ Autonoma Madrid, Dept Biol Mol, Ctr Biol Mol Severo Ochoa, Madrid, Spain
[3] Consejo Super Invest Cient CBM UAM CSIC, Madrid, Spain
关键词:
Aging;
apolipoprotein E;
brain;
HSV-1;
infection;
gender;
mouse;
MRI;
APOLIPOPROTEIN-E GENOTYPE;
ALZHEIMERS-DISEASE;
VERTICAL TRANSMISSION;
AGENTS CONTRIBUTE;
NERVOUS-SYSTEM;
E GENE;
SPECTROSCOPY;
PATHOGENESIS;
RECOGNITION;
PROGRESSION;
D O I:
10.3233/JAD-2012-120070
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
To date, the main advances in understanding Alzheimer's disease (AD) have revolved around the genetic variants associated with the familial form of the disease, yet the majority of cases are sporadic. The main risk factor for AD is aging, followed by production of the E4 isoform of apolipoprotein E (APOE). Female gender also increases the risk of developing AD. Herpes simplex virus type 1 (HSV-1) has been epidemiologically and experimentally associated with AD, although no studies on its effects over aging have been undertaken. To assess the potential aging-related consequences of HSV-1 brain infection, 2 month-old wild-type and apoE-deficient mice were infected with the virus, and over the next 16 months analyses made of cerebral viral load, neuropathological, morphological, and metabolic changes in the brain, and cognitive performance. Viral load in the central nervous system (CNS) increased with age. The viral load in the brains of aged apoE+/+ female mice was 43 times that seen in apoE-/- male mice. No MRI-detectable morphological differences nor any clear neuropathological differences were seen between 18 month-old infected and mock-infected mice, although differences were seen in younger animals. Neuroinfection was associated with memory deficit and a reduction in metabolic indicators of CNS health.
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页码:779 / 790
页数:12
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