Mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell models of Parkinson's disease

被引：34

作者：

Bose, Anindita ^{[1
]}

Beal, M. Flint ^{[2
]}

机构：

[1] Weill Cornell Med, Feil Family Brain & Mind Res Inst, Helen & Robert Appel Alzheimers Dis Res Inst, New York, NY 10065 USA

[2] Weill Cornell Med, Feil Family Brain & Mind Res Inst, New York, NY USA

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 2019年 / 49卷 / 04期

关键词：

IPSC; mitochondrial dysfunction; oxidative stress; PD; therapeutics; ALPHA-SYNUCLEIN; DOPAMINE NEURONS; LRRK2; SENSITIVITY; ACTIVATION;

D O I：

10.1111/ejn.14264

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parkinson's disease (PD) is the second most common neurodegenerative disease. Two percent of the population above the age of 60 is affected by the disease. The pathological hallmarks of PD include loss of dopaminergic neurons and the presence of Lewy bodies. Mitochondrial dysfunction and oxidative stress are thought to play a pivotal role in both sporadic and familial forms of the disease. In this review we focus on the role of mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell (IPSC) models of PD.We also provide an overview of therapeutics that have been tested and some possible new therapeutics that can be tested in IPSC models of PD.

引用

页码：525 / 532

页数：8

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