Confocal laser endomicroscopy in gastrointestinal diseases
被引:48
作者:
Goetz, Martin
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Univ Med Mainz, Med Klin & Poliklin, Mainz, GermanyUniv E Anglia, Fac Med & Hlth Sci, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England
Goetz, Martin
[2
]
Watson, Alastair
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Univ E Anglia, Fac Med & Hlth Sci, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, EnglandUniv E Anglia, Fac Med & Hlth Sci, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England
Watson, Alastair
[1
]
Kiesslich, Ralf
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Univ Med Mainz, Med Klin & Poliklin, Mainz, GermanyUniv E Anglia, Fac Med & Hlth Sci, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England
Kiesslich, Ralf
[2
]
机构:
[1] Univ E Anglia, Fac Med & Hlth Sci, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England
[2] Univ Med Mainz, Med Klin & Poliklin, Mainz, Germany
Confocal laser endomicroscopy (CLE) is a novel endoscopic technique permitting in vivo microscopy (optical biopsies) of the gastrointestinal mucosa. CLE has been studied in a multitude of diseases of the upper and lower gastrointestinal tract, including Barrett's esophagus, gastric inflammation and cancer, celiac disease, colorectal adenoma and carcinoma, and inflammatory bowel diseases. CLE has recently evolved and been studied for bile duct and liver imaging. CLE has shown overall high accuracy and enabled smart, targeted biopsies rather than untargeted sampling. Furthermore, the availability of real time microscopic information during endoscopy has immediate impact on therapeutic decisions and guides endoscopic interventions. CLE is also a unique tool for observation of (patho-)physiologic events in their natural environment (functional imaging) and has been linked to molecular imaging of gastrointestinal neoplasia in vivo, thereby broadening our understanding of mucosal pathology in clinical and basic science. Two types of CLE systems for confocal endomicroscopy: endomicroscope (upper panel) with laser scanner integrated into the distal part of an endoscope and probe-based CLE (lower panel).