The preparation of a core-shell stationary phase by thein situpolymerization of a hydrophilic polymer on the surface of silica and its chromatographic performance

被引：4

作者：

Fan, Chao ^{[1
,2
,3
]}

Tang, Hao ^{[4
]}

Wang, Licheng ^{[1
,2
]}

Li, Yijing ^{[1
,2
]}

Wang, Xusheng ^{[1
,2
]}

Wang, Shuai ^{[1
,2
]}

Liang, Xiaojing ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Gansu, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Gansu, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Gansu Prov Hosp, Dept Pharm, Lanzhou 730000, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2020年 / 44卷 / 27期

基金：

中国国家自然科学基金;

关键词：

COLLOIDAL CARBON SPHERES; MONOLITHIC COLUMN; COMPOSITE;

D O I：

10.1039/d0nj01197e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

UsingN-isopropylacrylamide (NIPAM) as a monomer, a core-shell material was successfully preparedvia in situpolymerization on the surface of silica microspheres (named NIPAM@Sil), which acts as a hydrophilic interaction chromatography (HILIC) stationary phase. A method for thein situpolymerization of polymer monomers on a silica surface has been developed. It was shown using scanning electron microscopy (SEM) that NIPAM is evenly distributed on the surface of the silica. The synthesized NIPAM@Sil possesses a polar acylamino group arising from the polymerization of NIPAM. As demonstrated by the hydrophilicity, NIPAM@Sil showed excellent HILIC performance for the separation of hydrophilic compounds. This method provides a simple approach for the preparation of a polymer coated silica core-shell stationary phase.

引用

页码：11704 / 11709

页数：6

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