The contribution of bone to whole-organism physiology

被引：390

作者：

Karsenty, Gerard ^{[1
]}

Ferron, Mathieu ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA

来源：

NATURE | 2012年 / 481卷 / 7381期

基金：

美国国家卫生研究院;

关键词：

TRYPTOPHAN-HYDROXYLASE INHIBITORS; SYMPATHETIC-NERVOUS-SYSTEM; RECEPTOR-RELATED PROTEIN-5; TYROSINE-PHOSPHATASE; 1B; ENERGY-METABOLISM; BODY-WEIGHT; INVOLUTIONAL OSTEOPOROSIS; POSTMENOPAUSAL WOMEN; SEROTONIN SYNTHESIS; GLUCOSE-METABOLISM;

D O I：

10.1038/nature10763

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.

引用

页码：314 / 320

页数：7

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