Circulating dendritic cells are severely decreased in idiopathic pulmonary fibrosis with a potential value for prognosis prediction

被引：15

作者：

Galati, Domenico ^{[1
]}

Zanotta, Serena ^{[1
]}

Polistina, Giorgio Emanuele ^{[2
]}

Coppola, Antonietta ^{[2
]}

Capitelli, Ludovica ^{[2
]}

Bocchino, Marialuisa ^{[2
]}

机构：

[1] Ist Nazl Tumori IRCCS Fdn G Pascale, Dept Haematol & Innovat Therapies, Haematol Oncol & Stem Cell Transplantat Unit, Naples, Italy

[2] Univ Naples Federico II, Dept Clin Med & Surg, Resp Med Div, Naples, Italy

来源：

CLINICAL IMMUNOLOGY | 2020年 / 215卷

关键词：

Idiopathic pulmonary fibrosis; Dendritic cells; Oxidative burst; Interleukin-6; Flow cytometry; OXIDATIVE STRESS; IL-6; STAT3; STANDARDIZATION; TUMOR; DIFFERENTIATION; GUIDELINES; STATEMENT; CYTOKINES; ALPHA;

D O I：

10.1016/j.clim.2020.108454

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) accumulate in the lung of patients affected by idiopathic pulmonary fibrosis (IPF). We measured the frequencies of circulating conventional CD1c + and CD141 + cells (namely, cDC2 and cDC1) and of plasmacytoid CD303 + DCs in a cohort of 60 therapy naive IPF patients by flow cytometry. Peripheral levels of reactive oxygen species (ROS) and of pro-inflammatory and Th1/Th2 polarizing cytokines were also analyzed. All blood DC subtypes were significantly reduced in IPF patients in comparison to age- and sex-matched controls, while ROS and interleukin (IL-6) levels were augmented. IL-6 expression increased along with disease severity, according to the gender-age-physiology index, and correlated with the frequency of cDC2. IL-6 and cDC2 were not influenced by anti-fibrotic therapies but were associated with a reduced survival, the latter being an independent predictive biomarker of worse prognosis. Deciphering the role of DCs in IPF might provide information on disease pathogenesis and clinical behavior.

引用

页数：10

共 53 条

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