Biomimetic three-dimensional microenvironment for controlling stem cell fate

被引：44
作者：
Zhang, Hu [1 ]
Dai, Sheng [1 ]
Bi, Jingxiu [1 ]
Liu, Kuo-Kang [2 ]
机构：
[1] Univ Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia
[2] Univ Warwick, Sch Engn, Coventry CV4 7AL, W Midlands, England
来源：
INTERFACE FOCUS | 2011年 / 1卷 / 05期
关键词：
stem cell; microenvironment; stem cell niche; microscale technologies; bioprinting; optical tweezers; MARROW STROMAL CELLS; FLUID-FLOW; EXTRACELLULAR-MATRIX; IN-VITRO; SHEAR-STRESS; OSTEOGENIC DIFFERENTIATION; EMBRYONIC FIBROBLASTS; OPTICAL TWEEZERS; GROWTH; SCAFFOLDS;
D O I：
10.1098/rsfs.2011.0035
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Stem cell therapy is an emerging technique which is being translated into treatment of degenerated tissues. However, the success of translation relies on the stem cell lineage commitment in the degenerated regions of interest. This commitment is precisely controlled by the stem cell microenvironment. Engineering a biomimetic three-dimensional microenvironment enables a thorough understanding of the mechanisms of governing stem cell fate. We review the individual microenvironment components, including soluble factors, extracellular matrix, cell-cell interaction and mechanical stimulation. The perspectives in creating the biomimetic microenvironments are discussed with emerging techniques.
引用
收藏
页码：792 / 803
页数：12
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