COMT Val158Met-Stress Interaction in Psychosis: Role of Background Psychosis Risk

被引:61
作者
Collip, Dina [1 ]
van Winkel, Ruud [1 ,2 ]
Peerbooms, Odette [1 ]
Lataster, Tineke [1 ]
Thewissen, Viviane [1 ,3 ]
Lardinois, Marielle [1 ]
Drukker, Marjan [1 ]
Rutten, Bart P. F. [1 ]
Van Os, Jim [1 ,4 ]
Myin-Germeys, Inez [1 ]
机构
[1] Maastricht Univ, Dept Psychiat & Neuropsychol, S Limburg Mental Hlth Res & Teaching Network, EURON,Sch Mental Hlth & NeuroSci MHeNS, NL-6200 MD Maastricht, Netherlands
[2] Katholieke Univ Leuven, Univ Psychiat Ctr, Kortenberg, Belgium
[3] Open Univ Netherlands, Fac Psychol, Heerlen, Netherlands
[4] Inst Psychiat, Div Psychol Med, London, England
关键词
Environment; Experience sampling method; Genes; Psychological stress; Psychotic disorders; Schizophrenia; CATECHOL-O-METHYLTRANSFERASE; DAILY-LIFE STRESS; GENE-ENVIRONMENT INTERACTIONS; VAL(158)MET GENOTYPE; FUNCTIONAL POLYMORPHISM; EMOTIONAL REACTIVITY; SCHIZOPHRENIA; MODERATION; ASSOCIATION; MECHANISMS;
D O I
10.1111/j.1755-5949.2010.00213.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: The interplay between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and environmental stress may have etiological relevance for psychosis, but differential effects have been reported in healthy control and patient groups, suggesting that COMT Val158Met interactions with stress may be conditional on background genetic risk for psychotic disorder. Methods: Patients with a nonaffective psychotic disorder (n = 86) and control participants (n = 109) were studied with the experience sampling method (a structured diary technique) in order to assess stress, negative affect and momentary psychotic symptoms in the flow of daily life. Results: Multilevel analyses revealed significant three-way interactions between group status (patient or control), COMT genotype and stress in the model of negative affect (?2(2) = 13.26, P < 0.01) as well as in the model of momentary psychotic symptoms (?2(2) = 6.92, P < 0.05). Exploration of the three-way interaction revealed that in patients, COMT genotype moderated the association between stress and negative affect (?2(4) = 11.50, P < 0.005), as well as the association between stress and momentary psychosis (?2(4) = 12.79, P < 0.005). Met/Met genotype patients showed significantly increased psychotic and affective reactivity to stress in comparison to the Val/Met and Val/Val genotypes. In contrast, healthy controls did not display large or significant COMT Val158Met X stress interactions. Conclusions: Important differences exist in the effect of COMT Val158Met on stress reactivity, which may depend on background risk for psychotic disorder. Differential sensitivity to environmental stress occasioned by COMT Val158Met may be contingent on higher order interactions with genetic variation underlying psychotic disorder.
引用
收藏
页码:612 / 619
页数:8
相关论文
共 38 条
[1]  
ANDREASEN NC, 1992, ARCH GEN PSYCHIAT, V49, P615
[2]   Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction [J].
Caspi, A ;
Moffitt, TE ;
Cannon, M ;
McClay, J ;
Murray, R ;
Harrington, H ;
Taylor, A ;
Arseneault, L ;
Williams, B ;
Braithwaite, A ;
Poulton, R ;
Craig, IW .
BIOLOGICAL PSYCHIATRY, 2005, 57 (10) :1117-1127
[3]   Opinion - Gene-environment interactions in psychiatry: joining forces with neuroscience [J].
Caspi, Avshalom ;
Moffitt, Terrie E. .
NATURE REVIEWS NEUROSCIENCE, 2006, 7 (07) :583-590
[4]   Determinants of occurrence and recovery from hallucinations in daily life [J].
Delespaul, P ;
deVries, M ;
van Os, J .
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY, 2002, 37 (03) :97-104
[5]   Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation [J].
Drabant, Emily M. ;
Hariri, Ahmad R. ;
Meyer-Lindenberg, Andreas ;
Munoz, Karen E. ;
Mattay, Venkata S. ;
Kolachana, Bhaskar S. ;
Egan, Michael F. ;
Weinberger, Daniel R. .
ARCHIVES OF GENERAL PSYCHIATRY, 2006, 63 (12) :1396-1406
[6]   Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: A large-scale association study plus meta-analysis [J].
Fan, JB ;
Zhang, CS ;
Gu, NF ;
Li, XW ;
Sun, WW ;
Wang, HY ;
Feng, GY ;
Clair, DS ;
He, L .
BIOLOGICAL PSYCHIATRY, 2005, 57 (02) :139-144
[7]   Paper or plastic? Data equivalence in paper and electronic diaries [J].
Green, AS ;
Rafaeli, E ;
Bolger, N ;
Shrout, PE ;
Reis, HT .
PSYCHOLOGICAL METHODS, 2006, 11 (01) :87-105
[8]   An experimental study of catechol-O-methyltransferase Val158Met moderation of Δ-9-tetrahydrocannabinol-induced effects on psychosis and cognition [J].
Henquet, Cecile ;
Rosa, Araceli ;
Krabbendam, Lydia ;
Papiol, Sergi ;
Fananas, Lourdes ;
Drukker, Marjan ;
Ramaekers, Johannes G. ;
van Os, Jim .
NEUROPSYCHOPHARMACOLOGY, 2006, 31 (12) :2748-2757
[9]   Evidence for a familial correlation between increased reactivity to stress and positive psychotic symptoms [J].
Lataster, T. ;
Collip, D. ;
Lardinois, M. ;
van Os, J. ;
Myin-Germeys, I. .
ACTA PSYCHIATRICA SCANDINAVICA, 2010, 122 (05) :395-404
[10]   Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders [J].
Mandelli, Laura ;
Serretti, Alessandro ;
Marino, Elena ;
Pirovano, Adele ;
Calati, Raffaella ;
Colombo, Cristina .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2007, 10 (04) :437-447