Increased neuronal signatures of targeted memory reactivation during slow-wave up states

被引:52
作者
Goeldi, Maurice [1 ,2 ]
van Poppel, Eva Anna Maria [1 ]
Rasch, Bjoern [1 ]
Schreiner, Thomas [3 ]
机构
[1] Univ Fribourg, Dept Psychol, Fribourg, Switzerland
[2] Neurosci Ctr Zurich ZNZ, Zurich, Switzerland
[3] Univ Birmingham, Ctr Human Brain Hlth, Sch Psychol, Birmingham, W Midlands, England
基金
瑞士国家科学基金会;
关键词
CLOSED-LOOP STIMULATION; SLEEP; OSCILLATIONS; SPINDLES; RIPPLES; PHASE; CONSOLIDATION; KNOWLEDGE; PROMOTES; BENEFITS;
D O I
10.1038/s41598-019-39178-2
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
It is assumed that slow oscillatory up-states represent crucial time windows for memory reactivation and consolidation during sleep. We tested this assumption by utilizing closed-loop targeted memory reactivation: Participants were re-exposed to prior learned foreign vocabulary during up- and down-states of slow oscillations. While presenting memory cues during slow oscillatory up-states improved recall performance, down-state cueing did not result in a clear behavioral benefit. Still, no robust behavioral benefit of up-as compared to down-state cueing was observable. At the electrophysiological level however, successful memory reactivation during up-states was associated with a characteristic power increase in the theta and sleep spindle band. No oscillatory changes were observable for down-state cues. Our findings provide experimental support for the assumption that slow oscillatory up-states may represent privileged time windows for memory reactivation, while the interplay of slow oscillations, theta and sleep spindle activity promotes successful memory consolidation during sleep.
引用
收藏
页数:10
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