Review of surfactin chemical properties and the potential biomedical applications

被引：223
作者：
Seydlova, Gabriela [1 ]
Svobodova, Jaroslava [1 ]
机构：
[1] Charles Univ Prague, Dept Genet & Microbiol, Fac Sci, CR-12844 Prague 2, Czech Republic
来源：
CENTRAL EUROPEAN JOURNAL OF MEDICINE | 2008年 / 3卷 / 02期
关键词：
antimicrobial resistance; biosurfactants; lipopeptide antibiotics; membrane; surfactin; therapeutic agents;
D O I：
10.2478/s11536-008-0002-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Surfactin, a highly powerful biosurfactant produced by various strains of the genus Bacillus, exhibits antibacterial, antiviral, antitumor and hemolytic action. This anionic cyclic lipopeptide is constituted by a heptapeptide interlinked with a P-hydroxy fatty acid. Due to its amhipathic nature surfactin incorporates into the phospholipid bilayer and induces permeabilization and perturbation of target cells. The rising antibiotic resistance as well as a number of remarkable surfactin activities shows that it deserves special interest and is considered as a candidate compound for combating several health related issues. In this review, the current state of knowledge of surfactin properties, biomedical potential and limitations for its application is presented.
引用
收藏
页码：123 / 133
页数：11
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