Degradation of estrogen conjugates using titanium dioxide as a photocatalyst

被引：14

作者：

Mitamura, K ^{[1
]}

Narukawa, H ^{[1
]}

Mizuguchi, T ^{[1
]}

Shimada, K ^{[1
]}

机构：

[1] Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9200934, Japan

来源：

ANALYTICAL SCIENCES | 2004年 / 20卷 / 01期

关键词：

D O I：

10.2116/analsci.20.3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Estrogen conjugates (estradiol-3-glucuronide, -17-glueuronide, estrone-glucuronide and -sulfate) were subjected to photodegradation using titanium dioxide immobilized on glass beads as a catalyst. Their time courses were measured by HPLC and compared with those of the unconjugated estrogens. Estradiol, its 17-glucuronide and estrone, which have an unconjugated phenolic hydroxy group at the C-3 position, were almost completely degraded by UV irradiation within 4 h. On the other hand, significant amounts of estradiol- and estrone-3-glucuronide (ca. 20%, 25%) and estrone sulfate (ca. 90%), which were conjugated at the 3-hydroxy group, remained after a 6.5 It irradiation. These results supported the hypothesis that the photodegradation of estrogens was initiated at the phenolic hydroxy group.

引用

页码：3 / 4

页数：2