Synthesis and pharmacological evaluation of prenylated and benzylated pterocarpans against snake venom

被引：40
|
作者：
da Silva, AJM
Coelho, AL
Simas, ABC
Moraes, RAM
Pinheiro, DA
Fernandes, FFA
Arruda, EZ
Costa, PRR
Melo, PA
机构：
[1] Univ Fed Rio de Janeiro, Ctr Ciencias Saude, Lab Quim Bioorgan, Nucl Pesquisas Prod Nat, BR-21941590 Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Dept Farmacol Basica & Clin, Ctr Ciencias Saude, BR-21941590 Rio De Janeiro, Brazil
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 02期
关键词：
D O I：
10.1016/j.bmcl.2003.10.044
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Edunol (3), a pterocarpan isolated from Harpalyce brasiliana, a plant used in the northeast of Brazil against snakebites, was obtained by synthesis and showed antimyotoxic, antiproteolytic and PLA2 inhibitor properties. These proprieties could be improved through the synthesis of a bioisoster (5), where the prenyl group was replaced by the benzyl group. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：431 / 435
页数：5
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