A novel electrochemical sensor based on MnOOH nanorod/expanded graphite for sensitive monitoring of metronidazole

被引：15

作者：

Hu, Xiaomin ^{[1
]}

Zhang, Yuanyuan ^{[1
]}

Zeng, Ting ^{[1
]}

Wan, Qijin ^{[1
]}

Wu, Kangbing ^{[2
]}

Yang, Nianjun ^{[3
]}

机构：

[1] Wuhan Inst Technol, Sch Chem & Environm Engn, Key Lab Green Chem Engn Proc, Hubei Key Lab Novel Reactor & Green Chem Technol,M, Wuhan 430073, Peoples R China

[2] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Hubei Key Lab Bioinorgan Chem & Mat Med, Wuhan 430074, Peoples R China

[3] Univ Siegen, Inst Mat Engn, D-57076 Siegen, Germany

来源：

基金：

中国国家自然科学基金;

关键词：

Electrochemical sensor; Metronidazole; MnOOH nanomaterials; Expanded graphite; REDUCED GRAPHENE OXIDE; CARBON; ELECTRODE; ACID;

D O I：

10.1016/j.diamond.2022.109303

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Strict quantification of metronidazole (MNZ, one kind of nitroimidazole antibiotic) plays extraordinary roles for human health due to the serious toxicity arose from overuse of MNZ. In this research, a novel electrochemical sensor is proposed for sensitive quantitation of MNZ. This sensor is constructed using a composite of MnOOH nanorods and expanded graphite (MnOOH/EG), synthesized by a hydrothermal method. The morphological analyses and electrochemical capability tests through various analytical techniques (e.g., microscopic and electrochemical methods) exposit that MnOOH/EG composite displays prominent electrocatalytic activity and sensing capability for quantification of MNZ. A synergistic effect between EG and MnOOH is revealed, where EG offers a high electrode active area and a strong electron-transport ability, while MnOOH features outstanding electrocatalytic behavior. This novel electrochemical sensor displays high sensitivity toward voltammetric quantification of MNZ with detection limit of 17 nM. Moreover, this developed MnOOH/EG electrochemical sensor also demonstrates prominent reproducibility and repeatability as well as high selectivity in the quanti-tative analysis of MNZ. Beyond that, the constructed sensor has been also successfully applied in quantitative analysis of MNZ in commercial drugs and environmental water samples. Consequently, the MnOOH/EG com-posite presented here has strong potential to be employed as a sensing material for constructing electrochemical sensor in widespread fields.

引用

页数：11

共 53 条

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