Detection of the circulating tumor cells in cancer patients

被引：25

作者：

Armakolas, Athanasios ^{[1
]}

Panteleakou, Zacharoula ^{[1
]}

Nezos, Adrianos ^{[1
]}

Tsouma, Aikaterini ^{[1
]}

Skondra, Maria ^{[1
]}

Lembessis, Peter ^{[1
]}

Pissimissis, Nikolaos ^{[1
]}

Koutsilieris, Michael ^{[1
]}

机构：

[1] Univ Athens, Dept Expt Physiol, Med Sch Natl & Kapodistrian, Goudi 11527, Greece

来源：

FUTURE ONCOLOGY | 2010年 / 6卷 / 12期

关键词：

circulating tumor cell; molecular staging; multiplex PCR; tumor marker; POLYMERASE-CHAIN-REACTION; REVERSE TRANSCRIPTION-PCR; METASTATIC BREAST-CANCER; RT-PCR; PERIPHERAL-BLOOD; MOLECULAR MARKERS; EPITHELIAL-CELLS; HEMATOGENOUS DISSEMINATION; METHODOLOGICAL PITFALLS; ADHESION MOLECULE;

D O I：

10.2217/FON.10.152

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As the presence of tumor cells circulating in the blood is associated with systemic disease and shortened survival, the establishment of a method to detect circulating tumor cells (CTCs) is of critical importance for a more concise staging and follow-up of cancer patients. Recently, the most robust strategies for the determination of CTCs are the PCR-based methods and the CellSearch (R) system that exploits the immunofluorescent characterization and isolation of cancer cells. Herein, we analyzed the experimental strategies used for determining CTCs with respect to accuracy, sensitivity and reproducibility in cancers of the breast, colon, prostate and melanoma.

引用

页码：1849 / 1856

页数：8

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