Polyphenol-rich diets improve glucose metabolism in people at high cardiometabolic risk: a controlled randomised intervention trial

被引：92

作者：

Bozzetto, Lutgarda ^{[1
]}

Annuzzi, Giovanni ^{[1
]}

Pacini, Giovanni ^{[2
]}

Costabile, Giuseppina ^{[1
]}

Vetrani, Claudia ^{[1
]}

Vitale, Marilena ^{[1
]}

Griffo, Ettore ^{[1
]}

Giacco, Angela ^{[1
]}

De Natale, Claudia ^{[1
]}

Cocozza, Sara ^{[1
]}

Della Pepa, Giuseppe ^{[1
]}

Tura, Andrea ^{[2
]}

Riccardi, Gabriele ^{[1
]}

Rivellese, Angela A. ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy

[2] CNR, Metab Unit, Inst Biomed Engn, Padua, Italy

来源：

DIABETOLOGIA | 2015年 / 58卷 / 07期

关键词：

Beta cell function; Diet; GLP-1; Glucose metabolism; Insulin secretion; Insulin sensitivity; Long chain n-3 polyunsaturated fatty acids; OGTT; Oral glucose insulin sensitivity; Polyphenols; PANCREATIC BETA-CELL; N-3; FATTY-ACIDS; INSULIN SENSITIVITY; SECRETION; INGESTION; FISH; TOLERANCE; PLASMA; HEALTH;

D O I：

10.1007/s00125-015-3592-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim/hypothesis Dietary polyphenols and long chain n-3 polyunsaturated fatty acids (LCn3) are associated with lower cardiovascular risk. This may relate to their influence on glucose metabolism and diabetes risk. We evaluated the effects of diets naturally rich in polyphenols and/or LCn3 of marine origin on glucose metabolism in people at high cardiometabolic risk. Methods According to a 2 x 2 factorial design, individuals with high waist circumference and at least one more component of the metabolic syndrome were recruited at the obesity outpatient clinic. Eighty-six participants were randomly assigned by MINIM software to an isoenergetic diet: (1) control, low in LCn3 and polyphenol (analysed n = 20); (2) rich in LCn3 (n = 19); (3) rich in polyphenols (n = 19); or (4) rich in LCn3 and polyphenols (n = 19). The assigned diets were known for the participants and blinded for people doing measurements. Before and after the 8 week intervention, participants underwent a 3 h OGTT and a test meal with a similar composition as the assigned diet for the evaluation of plasma glucose, insulin and glucagon-like peptide 1 (GLP-1) concentrations, and indices of insulin sensitivity and beta cell function. Results During OGTT, polyphenols significantly reduced plasma glucose total AUC (p = 0.038) and increased early insulin secretion (p = 0.048), while LCn3 significantly reduced beta cell function (p = 0.031) (two-factor ANOVA). Moreover, polyphenols improved post-challenge oral glucose insulin sensitivity (OGIS; p = 0.05 vs control diet by post hoc ANOVA). At test meal, LCn3 significantly reduced GLP-1 total postprandial AUC (p < 0.001; two-factor ANOVA). Conclusion/interpretation Diets naturally rich in polyphenols reduce blood glucose response, likely by increasing early insulin secretion and insulin sensitivity. These effects may favourably influence diabetes and cardiovascular risk. The implications of the decrease in insulin secretion and postprandial GLP-1 observed with diets rich in marine LCn3 need further clarification.

引用

页码：1551 / 1560

页数：10

共 39 条

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