Protective Effects of Broadly Neutralizing Immunoglobulin against Homologous and Heterologous Equine Infectious Anemia Virus Infection in Horses with Severe Combined Immunodeficiency

被引：9

作者：

Taylor, Sandra D. ^{[1
]}

Leib, Steven R. ^{[1
]}

Wu, Wuwei ^{[2
]}

Nelson, Robert ^{[1
]}

Carpenter, Susan ^{[2
]}

Mealey, Robert H. ^{[1
]}

机构：

[1] Washington State Univ, Dept Vet Microbiol & Pathol, Pullman, WA 99164 USA

[2] Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA

来源：

JOURNAL OF VIROLOGY | 2011年 / 85卷 / 13期

基金：

美国国家卫生研究院;

关键词：

ANTIBODY-RESPONSES; IMMUNE-RESPONSES; PASSIVE TRANSFER; CLINICAL-DISEASE; HIV-1; ENVELOPE; PLASMA; TYPE-1; FAILURE; FOALS; REPLICATION;

D O I：

10.1128/JVI.00077-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Using the equine infectious anemia virus (EIAV) lentivirus model system, we previously demonstrated protective effects of broadly neutralizing immune plasma in young horses (foals) with severe combined immunodeficiency (SCID). However, in vivo selection of a neutralization-resistant envelope variant occurred. Here, we determined the protective effects of purified immunoglobulin with more potent broadly neutralizing activity. Overall, protection correlated with the breadth and potency of neutralizing activity in vitro. Four of five SCID foals were completely protected against homologous challenge, while partial protection occurred following heterologous challenge. These results support the inclusion of broadly neutralizing antibodies in lentivirus control strategies.

引用

页码：6814 / 6818

页数：5

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