Genetic and brain structure anomalies in autism spectrum disorders. Towards an understanding of the aetiopathogenesis

被引：0

作者：

Nickl-Jockschat, T. ^{[1
]}

Michel, T. M. ^{[1
]}

机构：

[1] Univ Klinikum Aachen, Klin Psychiat & Psychotherapie, D-2074 Aachen, Germany

来源：

NERVENARZT | 2011年 / 82卷 / 05期

关键词：

Autism spectrum disorders; Genes; MRI; Brain structure; QUANTITATIVE TRAIT LOCUS; RECEPTOR SUBUNIT GENES; REELIN GENE; LINKAGE-DISEQUILIBRIUM; ANGELMAN-SYNDROME; HEAD CIRCUMFERENCE; POSTERIOR-FOSSA; YOUNG-CHILDREN; FAMILIAL RISK; MUTATIONS;

D O I：

10.1007/s00115-010-2989-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Autism spectrum disorders (ASD) are pervasive development disorders with high heritability and an as yet unclear aetiology. So far molecular genetic research was able to identify several candidate genes for the disorder which are functionally linked to neurotransmission and neuronal migration, cortical organisation and synaptic plasticity. MRI studies repeatedly showed a higher total brain volume for ASD patients. The volume increase was most pronounced for the frontal and the temporal lobes and peaked in early childhood. A combination of molecular genetic and structural imaging research appears promising for a further characterization of ASD aetiology.

引用

页码：618 / 627

页数：10

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