Nano-hydroxyapatite as a delivery system: overview and advancements

被引:75
作者
Munir, Muhammad Usman [1 ]
Salman, Sajal [2 ]
Javed, Ibrahim [3 ]
Bukhari, Syed Nasir Abbas [1 ]
Ahmad, Naveed [4 ]
Shad, Naveed Akhter [5 ]
Aziz, Farooq [6 ]
机构
[1] Jouf Univ, Coll Pharm, Dept Pharmaceut Chem, Sakaka, Aljouf, Saudi Arabia
[2] Univ Cent Punjab, Fac Pharm, Lahore, Pakistan
[3] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld, Australia
[4] Jouf Univ, Coll Pharm, Dept Pharmaceut, Sakaka, Saudi Arabia
[5] Natl Inst Biotechnol & Genet Engn, Faisalabad, Pakistan
[6] Univ Sahiwal, Dept Phys, Sahiwal, Pakistan
关键词
Hydroxyapatite; calcium phosphate; nanocarrier; drug delivery systems; antibiotic; anticancer; CALCIUM-PHOSPHATE NANOPARTICLES; EFFICIENT DRUG-DELIVERY; CONTROLLED-RELEASE; NONVIRAL VECTOR; LOCAL-DELIVERY; COMPOSITE; ALENDRONATE; ADSORPTION; CISPLATIN; ZOLEDRONATE;
D O I
10.1080/21691401.2021.2016785
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Nano-hydroxyapatite is being investigated as vital components of implants and dental and tissue engineering devices. It is found as a bone replacement due to its non-toxicity and cytocompatibility with dental tissues and bone. The reality that nanocrystalline hydroxyapatite can be made of porous granules and scaffolds. Additionally, it has a massive loading potential indicating its use as a transporter for drugs or a regulated drug release mechanism in pharmaceutical research. This review aims to present existing nano-hydroxyapatite research developments as a drug carrier employed in bone tissue disorders locally and deliver poorly soluble drugs with reduced bioavailability. We have discussed the nano-hydroxyapatite role in the delivery of drugs (i.e. anti-resorptive, anti-cancer, and antibiotics), proteins, genetic material, and radionuclides.
引用
收藏
页码:717 / 727
页数:11
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