Transaminase-Catalyzed Racemization with Potential for Dynamic Kinetic Resolutions
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作者:
Ruggieri, Federica
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AlbaNova Univ Ctr, KTH Royal Inst Technol, Dept Ind Biotechnol, SE-10691 Stockholm, Sweden
SARom Biostruct AB, SE-22381 Lund, SwedenAlbaNova Univ Ctr, KTH Royal Inst Technol, Dept Ind Biotechnol, SE-10691 Stockholm, Sweden
Ruggieri, Federica
[1
,2
]
van Langen, Luuk M.
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Viazym BV, NL-2629 JD Delft, NetherlandsAlbaNova Univ Ctr, KTH Royal Inst Technol, Dept Ind Biotechnol, SE-10691 Stockholm, Sweden
van Langen, Luuk M.
[3
]
Logan, Derek T.
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SARom Biostruct AB, SE-22381 Lund, SwedenAlbaNova Univ Ctr, KTH Royal Inst Technol, Dept Ind Biotechnol, SE-10691 Stockholm, Sweden
Logan, Derek T.
[2
]
Walse, Bjorn
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SARom Biostruct AB, SE-22381 Lund, SwedenAlbaNova Univ Ctr, KTH Royal Inst Technol, Dept Ind Biotechnol, SE-10691 Stockholm, Sweden
Walse, Bjorn
[2
]
Berglund, Per
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AlbaNova Univ Ctr, KTH Royal Inst Technol, Dept Ind Biotechnol, SE-10691 Stockholm, SwedenAlbaNova Univ Ctr, KTH Royal Inst Technol, Dept Ind Biotechnol, SE-10691 Stockholm, Sweden
Berglund, Per
[1
]
机构:
[1] AlbaNova Univ Ctr, KTH Royal Inst Technol, Dept Ind Biotechnol, SE-10691 Stockholm, Sweden
Dynamic kinetic resolution (DKR) reactions in which a stereoselective enzyme and a racemization step are coupled in one pot would represent powerful tools for the production of enantiopure amines through enantioconvergence of racemates. The exploitation of DKR strategies is currently hampered by the lack of effective, enzyme-compatible and scalable racemization strategies for amines. In the present work, the proof of concept of a fully biocatalytic method for amine racemization is presented. Both enantiomers of the model compound 1-methyl-3-phenylpropylamine could be racemized in water and at room temperature using a couple of wild-type, non-proprietary, enantiocomplementary amine transaminases and a minimum amount of pyruvate/alanine as a co-substrate couple. The biocatalytic simultaneous parallel cascade reaction presented here poses itself as a customizable amine racemization system with potential for the chemical industry in competition with traditional transition-metal catalysis.
机构:
Stockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, SwedenStockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden
Paetzold, J
Bäckvall, JE
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Stockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, SwedenStockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden
机构:
Univ Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, SwedenUniv Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden
Pàmies, O
Éll, AH
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Univ Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, SwedenUniv Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden
Éll, AH
Samec, JSM
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Univ Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, SwedenUniv Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden
Samec, JSM
Hermanns, N
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Univ Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, SwedenUniv Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden
Hermanns, N
Bäckvall, JE
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Univ Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, SwedenUniv Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden
机构:
Stockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, SwedenStockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden
Paetzold, J
Bäckvall, JE
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Stockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, SwedenStockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden
机构:
Univ Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, SwedenUniv Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden
Pàmies, O
Éll, AH
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Univ Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, SwedenUniv Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden
Éll, AH
Samec, JSM
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h-index: 0
机构:
Univ Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, SwedenUniv Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden
Samec, JSM
Hermanns, N
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机构:
Univ Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, SwedenUniv Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden
Hermanns, N
Bäckvall, JE
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Univ Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, SwedenUniv Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden