Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future

被引：92

作者：

Ariza, Manuela ^{[1
]}

Kolb, Hartmuth C. ^{[2
]}

Moechars, Dieder ^{[3
]}

Rombouts, Frederik ^{[1
]}

Ignacio Andres, Jose ^{[4
]}

机构：

[1] Janssen Res & Dev, Neurosci Med Chem, B-2340 Beerse, Belgium

[2] Janssen Res & Dev, Neurosci Biomarkers, San Diego, CA 92121 USA

[3] Janssen Res & Dev, Neurosci Discovery Biol, B-2340 Beerse, Belgium

[4] Janssen Res & Dev, Discovery Sci, Jarama 75, Toledo 45007, Spain

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 58卷 / 11期

关键词：

ALZHEIMERS ASSOCIATION WORKGROUPS; PAIRED HELICAL FILAMENTS; TRANSGENIC MOUSE MODELS; CENTRAL-NERVOUS-SYSTEM; NEUROFIBRILLARY TANGLES; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; A-BETA; PHENYLDIAZENYL BENZOTHIAZOLE; BENZIMIDAZOLE DERIVATIVES;

D O I：

10.1021/jm5017544

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia among the elderly population. The good correlation of the density and neocortical spread of neurofibrillary tangles (NFTs) with clinical AD disease progression offers an opportunity for the early diagnosis and staging using a noninvasive imaging technique such as positron emission tomography (PET). Thus, PET imaging of NFTs not only holds promise as a diagnostic tool but also may enable the development of disease modifying therapeutics for AD. In this review, we focus on the structural diversity of tau PET tracers, the challenges related to the identification of high affinity and highly selective NFT ligands, and recent progress in the clinical development of tau PET radioligands.

引用

页码：4365 / 4382

页数：18

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