Adenoviral vector-based strategies against infectious disease and cancer

被引：86
作者：
Zhang, Chao [1 ]
Zhou, Dongming [1 ]
机构：
[1] Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Vaccine Res Ctr, Shanghai, Peoples R China
来源：
HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2016年 / 12卷 / 08期
关键词：
adenovirus; cancer therapy; clinical trial; infectious disease; vaccine; T-CELL RESPONSES; RESPIRATORY SYNDROME CORONAVIRUS; RECOMBINANT HUMAN ADENOVIRUS; PRIME-BOOST VACCINATION; MEDIATED GENE DELIVERY; EBOLA-VIRUS INFECTION; TYPE-5 FIBER PROTEIN; HIV-1 ENV VACCINE; TEST-OF-CONCEPT; IMMUNE-RESPONSES;
D O I：
10.1080/21645515.2016.1165908
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Adenoviral vectors are widely employed against infectious diseases or cancers, as they can elicit specific antibody responses and T cell responses when they are armed with foreign genes as vaccine carriers, and induce apoptosis of the cancer cells when they are genetically modified for cancer therapy. In this review, we summarize the biological characteristics of adenovirus (Ad) and the latest development of Ad vector-based strategies for the prevention and control of emerging infectious diseases or cancers. Strategies to circumvent the pre-existing neutralizing antibodies which dampen the immunogenicity of Ad-based vaccines are also discussed.
引用
收藏
页码：2064 / 2074
页数：11
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