Determinants of all-cause in-hospital mortality among patients who presented with COVID-19 to a community teaching hospital in Michigan

被引:6
作者
Zakaria, Ali [1 ]
Piper, Marc [1 ]
Douda, Lahib [3 ]
Jackson, Nancy M. [3 ]
Flynn, Jeffrey C. [3 ]
Misra, Dawn P. [2 ]
Gardiner, Joseph [2 ]
Sankari, Abdulghani [3 ]
机构
[1] Michigan State Univ, Coll Human Med, Ascens Providence Hosp, Dept Internal Med,Div Gastroenterol, Southfield, MI USA
[2] Michigan State Univ, Coll Human Med, Dept Epidemiol & Biostat, Lansing, MI USA
[3] Ascens Providence Hosp, Dept Med Educ, Southfield, MI 48075 USA
关键词
COVID-19; Race-gender interaction; Racial disparity; Mortality; HEALTH-CARE; DISPARITIES; STATES;
D O I
10.1016/j.heliyon.2021.e08566
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background & objectives: Race plays an important role in healthcare disparities, often resulting in worse health outcomes. It is unclear if other patient factors and race interactions may influence mortality in patients with COVID-19. We aimed to evaluate how multiple determinants of all-cause in-hospital mortality from COVID-19 were linked to race. Methods: A retrospective observational study was conducted at two hospitals in metropolitan Detroit. We identified patients aged >18 years-old who had tested positive for COVID-19 and were admitted between March 9 through May 16, 2020. Multivariable logistic regression was performed assessing predictors of all-cause in-hospital mortality in COVID-19. Results: We identified 1064 unique patients; 74% were African Americans (AA). The all-cause in-hospital mortality was 21.7%, with the majority of deaths seen in AA (65.4%, P = 0.002) and patients 80 years or older (52%, P < 0.0001). AA women had lower all-cause mortality than AA men, white women, and white men based on racegender interactions. In multivariable logistic regression analysis, older age (>80-year-old), dementia, and chronic kidney disease were associated with worse all-cause in-hospital mortality. Adjusted for race and body mass index (BMI), the main odds ratios (OR) and 95% confidence intervals (CI) are: Age 80 and older vs < 60 in females: OR = 7.4, 95% CI: 2.9, 18.7; in males OR = 7.3, 95% CI: 3.3, 16.2; Chronic Kidney Disease (CKD): OR = 1.7, 95% CI: 1.2, 2.6; Dementia: OR = 2.2, 95% CI: 1.5, 3.3. Conclusion: Gender significantly modified the association of race and COVID-19 mortality. African American females had the lowest all-cause in-hospital mortality risk compared to other gender-race groups.
引用
收藏
页数:8
相关论文
共 50 条
[31]   Anosmia is associated with lower in-hospital mortality in COVID-19 [J].
Talavera, Blanca ;
Garcia-Azorin, David ;
Martinez-Pias, Enrique ;
Trigo, Javier ;
Hernandez-Perez, Isabel ;
Valle-Penacoba, Gonzalo ;
Simon-Campo, Paula ;
de Lera, Mercedes ;
Chavarria-Miranda, Alba ;
Lopez-Sanz, Cristina ;
Gutierrez-Sanchez, Maria ;
Martinez-Velasco, Elena ;
Pedraza, Maria ;
Sierra, Alvaro ;
Gomez-Vicente, Beatriz ;
Guerrero, Angel ;
Francisco Arenillas, Juan .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2020, 419
[32]   Association between COVID-19 and incidence of cardiovascular disease and all-cause mortality among patients with diabetes [J].
Jung, Hee Sun ;
Choi, Jae Woo .
FRONTIERS IN ENDOCRINOLOGY, 2023, 14
[33]   Hospital readmissions and post-discharge all-cause mortality in COVID-19 recovered patients; A systematic review and meta-analysis [J].
Ramzi, Zhian Salah .
AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2022, 51 :267-279
[34]   Impact of COVID-19 In-hospital Mortality in Chagas Disease Patients [J].
da Silva, Gilberto Marcelo Sperandio ;
Mediano, Mauro Felippe Felix ;
Murgel, Michele Ferreira ;
Andrade, Patricia Mello ;
de Holanda, Marcelo Teixeira ;
Valete Rosalino, Claudia Maria ;
de Sousa, Andrea Silvestre ;
Mendes, Fernanda de Souza Nogueira Sardinha ;
Pinheiro, Roberta Olmo ;
Veloso, Valdilea Goncalves ;
Saraiva, Roberto Magalhaes ;
Hasslocher-Moreno, Alejandro Marcel .
FRONTIERS IN MEDICINE, 2022, 9
[35]   Increased in-hospital mortality from COVID-19 in patients with schizophrenia [J].
Fond, G. ;
Pauly, V ;
Orleans, V ;
Antonini, F. ;
Fabre, C. ;
Sanz, M. ;
Klay, S. ;
Jimeno, M-T ;
Leone, M. ;
Lancon, C. ;
Auquier, P. ;
Boyer, L. .
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE, 2021, 47 (02) :89-95
[36]   Association of liver abnormalities with in-hospital mortality in patients with COVID-19 [J].
Ding, Ze-yang ;
Li, Gan-xun ;
Chen, Lin ;
Shu, Chang ;
Song, Jia ;
Wang, Wei ;
Wang, Yu-wei ;
Chen, Qian ;
Jin, Guan-nan ;
Liu, Tong-tong ;
Liang, Jun-nan ;
Zhu, Peng ;
Zhu, Wei ;
Li, Yong ;
Zhang, Bin-hao ;
Feng, Huan ;
Zhang, Wan-guang ;
Yin, Zhen-yu ;
Yu, Wen-kui ;
Yang, Yang ;
Zhang, Hua-qiu ;
Tang, Zhou-ping ;
Wang, Hui ;
Hu, Jun-bo ;
Liu, Ji-hong ;
Yin, Ping ;
Chen, Xiao-ping ;
Zhang, Bixiang .
JOURNAL OF HEPATOLOGY, 2021, 74 (06) :1295-1302
[37]   ASSOCIATION BETWEEN HYPERTENSION AND IN-HOSPITAL MORTALITY IN COVID-19 PATIENTS [J].
Allo, Iswandy Janetputra Turu' ;
Tiksnadi, Badai Bhatara ;
Prakoso, Pranata Priyo ;
Najiyah, Hana Hadianty ;
Rahmawati, Mira ;
Hasmirani, Mira ;
Wibowo, Robin Hendra ;
Utomo, Priyanto ;
Yudisman, Ade .
JOURNAL OF HYPERTENSION, 2021, 39 :E18-E19
[38]   The association between famotidine and in-hospital mortality of patients with COVID-19 [J].
Kuno, Toshiki ;
So, Matsuo ;
Takahashi, Mai ;
Egorova, Natalia N. .
JOURNAL OF MEDICAL VIROLOGY, 2022, 94 (03) :1186-1189
[39]   Racial Differences and In-Hospital Outcomes Among Hospitalized Patients with COVID-19 [J].
Elbadawi, Ayman ;
Elgendy, Islam Y. ;
Joseph, Douglas ;
Eze-Nliam, Chete ;
Rampersad, Penelope ;
Ouma, Geoffrey ;
Bhandari, Rohan ;
Kirksey, Lee ;
Chaudhury, Pulkit ;
Chung, Mina K. ;
Kalra, Ankur ;
Mehta, Neil ;
Bartholomew, John R. ;
Sahai, Aditya ;
Svensson, Lars G. ;
Cameron, Scott J. .
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES, 2022, 9 (05) :2011-2018
[40]   Hemogram as marker of in-hospital mortality in COVID-19 [J].
Lopez-Escobar, Alejandro ;
Madurga, Rodrigo ;
Castellano, Jose Maria ;
Ruiz de Aguiar, Santiago ;
Velazquez, Sara ;
Bucar, Marina ;
Jimeno, Sara ;
Ventura, Paula Sol .
JOURNAL OF INVESTIGATIVE MEDICINE, 2021, 69 (05) :962-969