Synthesis and antibacterial activity of new spiro[thiadiazoline-quinoxaline] derivatives

被引：23

作者：

Caleb, Ahoya A. ^{[1
]}

Ballo, Daouda ^{[1
]}

Rachid, Bouhfid ^{[2
]}

Amina, Hancali ^{[3
]}

Mostapha, Bousmina ^{[2
]}

Abdelfettah, Zerzouf

Rajae, El Aouad ^{[3
]}

El Mokhtar, Essassi ^{[1
,2
]}

机构：

[1] Univ Mohammed V Agdal, Fac Sci, Lab Chim Organ Heterocycl, Av Ibn Battouta,BP 1014, Rabat, Morocco

[2] MASCIR Fdn, INANOTECH Inst Nanomat & Nanotechnol, Rabat 10100, Morocco

[3] Natl Inst Hyg, Microbiol Lab, Rabat, Morocco

来源：

ARKIVOC | 2011年

关键词：

3-Methylquinoxaline-2-thione; 1,3-dipolar cycloaddition; spiro[thiadiazoline-quinoxaline; antibacterial activity; ANTICANCER; ANTIFUNGAL;

D O I：

10.3998/ark.5550190.0012.217

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 1,3-dipolar cycloaddition of 3-methylquinoxaline-2-thione and their N-alkylated derivatives to diphenylnitrile imine is presented. Using this method, spiro[thiadiazoline-quinoxaline] derivatives as biologically interesting compounds were produced in high to excellent yields. These compounds have been characterized on the basis of their spectroscopic et spectrometric data (H-1 and C-13 NMR, IR, MS and X-ray). Antibacterial activity of the synthesized products has been studied by employing five bacterial strains. The compounds with ethyl group showed the best activity with MIC value of 32 mu g/mL against Streptococcus fasciens.

引用

页码：217 / 226

页数：10

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