Comparison of IL-23 receptor gene polymorphisms in patients with primary sjogren syndrome, ankylosing spondylitis. and ankylosing spondylitis with sjogren's syndrome

被引:0
作者
Temel, Sahin [1 ]
Balkarli, Ayse [2 ]
Elmas, Levent [3 ]
Tepeli, Emre [4 ]
Cobankara, Veli [5 ]
机构
[1] Pamukkale Univ, Sch Med, Dept Internal Med, TR-20200 Kinikli, Denizli, Turkey
[2] Antalya Training & Res Hosp, Dept Internal Med, Div Rheumatol, Kazim Karabekir Ave, TR-07700 Antalya, Turkey
[3] Pamukkale Univ, Sch Med, Dept Med Biol, TR-20200 Kinikli, Denizli, Turkey
[4] Pamukkale Univ, Sch Med, Dept Med Genet, TR-20200 Kinikli, Denizli, Turkey
[5] Pamukkale Univ, Sch Med, Dept Internal Med, Div Rheumatol, TR-20200 Kinikli, Denizli, Turkey
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 05期
关键词
Ankylosing spondylitis; sjogren syndrome; IL-23R gene polymorphism; ASSOCIATION; IL23R; VARIANTS; SPONDYLOARTHROPATHY; IDENTIFICATION; METAANALYSIS; POPULATION; THERAPY;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objectives: The frequency of Interleukin-23 receptor (IL-23R) gene polymorphism was previously studied in Ankylosing spondylitis (AS) and Sjogren syndrome (SS). However, it hasn't been studied in patients AS with SS. Methods: The study included 124 patients with AS, 55 patients with SS and 12 patients with association of AS and SS. Results: It was found that there was an increase in the frequency of rs10889677 gene mutant genotype while a decrease in the frequency of in rs11209032 gene mutant genotype in AS group compared to the healthy controls. In SS group, it was found that there was an increase the frequencies of rs11805303 gene wild genotype and rs2201841 gene wild genotype while a decrease in the frequencies of rs11209032 gene heterozygote genotype and rs10489629 gene mutant genotype when compared to healthy controls. CGCAA haplotype was associated with risk for AS (P=0.0125; RR: 1.32). CGCAG haplotype was associated with protective effect against ankylosing spondylitis (P=0.0042; RR: 0.52). While CTCAA haplotype was found to be protective against SS (P=0.022; RR: 0.46), it was associated with increased risk for association of AS and SS (P=0.0095; RR: 2.79). CTCAG haplotype was associated with protective effect against association of AS and SS (P=0.0151; RR: 0.02). It was observed that TGCGG haplotype increased significantly in SS group compared to the healthy controls and that it was related with increased risk for SS (P=0.032, RR: 2.56). Conclusion: Genotype distribution and genetic diversity vary among ethnic groups. Studies with larger sample size are needed to further clarify this issue.
引用
收藏
页码:8431 / 8443
页数:13
相关论文
共 50 条
  • [31] Increased frequency of restless leg syndrome in patients with ankylosing spondylitis
    Tekatas, Aslan
    Pamuk, Omer N.
    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2015, 18 (01) : 58 - 62
  • [32] High prevalence of metabolic syndrome in patients with ankylosing spondylitis
    Domenico Malesci
    Alferio Niglio
    Gianna Angela Mennillo
    Rosario Buono
    Gabriele Valentini
    Giovanni La Montagna
    Clinical Rheumatology, 2007, 26
  • [33] High prevalence of metabolic syndrome in patients with ankylosing spondylitis
    Malesci, Domenico
    Niglio, Alferio
    Mennillo, Gianna Angela
    Buono, Rosario
    Valentini, Gabriele
    La Montagna, Giovanni
    CLINICAL RHEUMATOLOGY, 2007, 26 (05) : 710 - 714
  • [34] IL-23R and IL-17A polymorphisms correlate with susceptibility of ankylosing spondylitis in a Southwest Chinese population
    Yang, Bin
    Xu, Yuanwei
    Liu, Xinle
    Huang, Zhuochun
    Wang, Lanlan
    ONCOTARGET, 2017, 8 (41) : 70310 - 70316
  • [35] A novel role for bone-derived cells in ankylosing spondylitis: Focus on IL-23
    Jo, Sungsin
    Koo, Bon San
    Lee, Bitnara
    Kwon, Eunji
    Lee, Young Lim
    Chung, Heekyoung
    Sung, Il-Hoon
    Park, Ye-Soo
    Kim, Tae-Hwan
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 491 (03) : 787 - 793
  • [36] Behçet‘s Syndrome coexisting with clinically occult ankylosing spondylitis
    Özlem Bölgen Çimen
    Günşah Şahin
    Ali Biçer
    Canan Erdoğan
    Zeitschrift für Rheumatologie, 2002, 61 : 440 - 442
  • [37] Serotonin transporter gene polymorphisms: Relation with platelet serotonin level in patients with primary Sjogren's syndrome
    Markeljevic, J.
    Sarac, H.
    Bozina, N.
    Henigsberg, N.
    Simic, M.
    Cicin-Sain, L.
    JOURNAL OF NEUROIMMUNOLOGY, 2015, 282 : 104 - 109
  • [38] Interleukin-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis
    Zhenhua Duan
    Faming Pan
    Zhen Zeng
    Tianchen Zhang
    Sheng Wang
    Guixing Li
    Shengqian Xu
    Jianhua Xu
    Li Zhang
    Rheumatology International, 2012, 32 : 1209 - 1214
  • [39] Coexistent Marfan's syndrome and ankylosing spondylitis: A case report
    Fietta, P
    Manganelli, P
    CLINICAL RHEUMATOLOGY, 2001, 20 (02) : 140 - 142
  • [40] Ankylosing spondylitis associated with Sweet’s syndrome: a case report
    Samia Mansouri
    Fatima Ezzahra Abourazzak
    Nassira Aradoini
    Asmae Bettioui
    Maryam Fourtassi
    Latifa Tahiri
    Fatima Zahra Mernissi
    Siham Tizniti
    Taoufik Harzy
    Journal of Medical Case Reports, 7 (1)