Regulation of Fatty Acid Metabolism by Cell Autonomous Circadian Clocks: Time to Fatten up on Information?

被引：39

作者：

Bray, Molly S. ^{[2
]}

Young, Martin E. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL 35294 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2011年 / 286卷 / 14期

基金：

美国国家卫生研究院;

关键词：

CONTROLS LIPID-METABOLISM; GENE-EXPRESSION; CONTRACTILE FUNCTION; DIURNAL REGULATION; ENERGY-METABOLISM; NUCLEAR RECEPTOR; DIETARY-FAT; RHYTHMS; MICE; TRIGLYCERIDE;

D O I：

10.1074/jbc.R110.214643

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular, cellular, and animal-based studies have recently exposed circadian clocks as critical regulators of energy balance. Invariably, mouse models of genetically manipulated circadian clock components display features indicative of altered lipid/fatty acid metabolism, including differential adiposity and circulating lipids. The purpose of this minireview is to provide a comprehensive summary of current knowledge regarding the regulation of fatty acid metabolism by distinct cell autonomous circadian clocks. The implications of these recent findings for cardiometabolic disease and human health are discussed.

引用

页码：11883 / 11889

页数：7

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