A 17-year-old girl with a background of aortic coarctation repaired with insertion of a prosthetic graft presented with persisting fever and nonspecific back pain. Whole body Ga-67 scintigraphy was performed to evaluate occult infection. Intense uptake was noted in the region of the superior mediastinum. Fusing Ga-67 tomographic reconstruction with CT images allowed accurate determination of the area of enhanced uptake to be at the site of the aortic graft.