Efficient two directional syntheses of a homophthalate ester and novel resorcylate oligomers

被引：15

作者：

Patel, Bhavesh H. ^{[1
]}

Heath, Scott F. A. ^{[1
]}

Mason, Andrew M. ^{[2
]}

Barrett, Anthony G. M. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] GlaxoSmithKline R&D, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 17期

基金：

英国工程与自然科学研究理事会;

关键词：

Resorcylate; Double dioxinone; Homophthalate ester; Aromatization; BIOMIMETIC SYNTHESIS; NATURAL-PRODUCTS; AROMATIZATION;

D O I：

10.1016/j.tetlet.2011.01.100

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thermolysis of 6,6'-(2-oxopropane-1,3-diyl)bis(2,2-dimethyl-4H-1,3-dioxin-4-one) in the presence of methanol gave a triketo-ester which subsequently aromatized to provide a synthetically useful homophthalate ester. Enolate C-acylation in the presence of diethylzinc was used to synthesize other double diketo-dioxinones, which on cyclization, aromatization and dioxinone ring opening gave novel double resorcylate derivatives. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2258 / 2261

页数：4

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