NanoSPECT/CT Imaging and Biodistribution of 188Re-HSA microspheres using new radio labeling process in a GP7TB Hepatoma Rats Model (Imaging and Biodistribution of 188Re-HSA microspheres)

被引：0

作者：

Chang, Ya-Jen ^{[1
]}

Chen, Su-Jung ^{[1
]}

Li, Chung-Yen ^{[1
]}

Chen, Liang-Cheng ^{[1
]}

Lee, Wan-Chi ^{[1
]}

Chang, Chih-Hsien ^{[1
]}

Lee, Te-Wei ^{[1
]}

机构：

[1] Inst Nucl Energy Res, Taoyuan, Taiwan

来源：

2015 IEEE INTERNATIONAL CONFERENCE ON IMAGING SYSTEMS AND TECHNIQUES (IST) PROCEEDINGS | 2015年

关键词：

Rhenium-188; hepatoma; microspheres; distribution; HEPATOCELLULAR-CARCINOMA; Y-90; RADIOEMBOLIZATION; THERAPY; TUMORS;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

The human serum albumin microsphere (HSA microsphere) is biodegradable and biocompatible, the SPECT/CT imaging and biodistribution of Re-188-HSA microspheres using new radio labeling process were investigated in a GP7TB hepatoma rat model. The labeling efficiency of the Re-188-HSA microspheres using new radio labeling process was about 97%. The levels of radioactivity within the liver peaked at 1 h (68.325777 +/- 1.896218 %ID/organ) and then declined slowly. With image analysis, the highest uptake in liver was 69.9 +/- 3.8 %ID/organ and 59.7 +/- 5.7 %ID/organ at 48 and 72 h after administration of Re-188-HSA microspheres via TACE. The liver uptake of Re-188-HSA microspheres was steadily maintained that to increase the radioactivity to directly give damage to tumor cells. These results showed potential benefit and advantage of Re-188-HSA microspheres via liver transarterial chemoembolization (TACE) for treatment of Hepatocellular carcinoma.

引用

页码：161 / 165

页数：5