Obesity Increases the Duration of Influenza A Virus Shedding in Adults

被引：158

作者：

Maier, Hannah E. ^{[1
]}

Lopez, Roger ^{[3
,5
]}

Sanchez, Lopez ^{[5
]}

Ng, Sophia ^{[1
]}

Gresh, Lionel ^{[5
]}

Ojeda, Sergio ^{[5
]}

Burger-Calderon, Raquel ^{[2
,5
]}

Kuan, Guillermina ^{[4
,5
]}

Harris, Eva ^{[2
]}

Balmaseda, Angel ^{[3
,5
]}

Gordon, Aubree ^{[1
]}

机构：

[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

[2] Univ Calif Berkeley, Sch Publ Hlth, Div Infect Dis & Vaccinol, Berkeley, CA 94720 USA

[3] Minist Hlth, Ctr Nacl Diagnost & Referencia, Managua, Nicaragua

[4] Minist Hlth, Ctr Salud Socrates Flores Vivas, Managua, Nicaragua

[5] Sustainable Sci Inst, Managua, Nicaragua

来源：

JOURNAL OF INFECTIOUS DISEASES | 2018年 / 218卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Influenza virus; obesity; viral shedding; paucisymptomatic; asymptomatic; transmission; household; epidemiology; public health; INFECTIONS; HOUSEHOLDS; CHILDREN;

D O I：

10.1093/infdis/jiy370

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Epidemiologic studies indicate that obesity increases the risk of severe complications and death from influenza virus infections, especially in elderly individuals. This work investigates the effect of obesity on the duration of viral shedding within household transmission studies in Managua, Nicaragua, over 3 seasons (2015-2017). Symptomatic obese adults were shown to shed influenza A virus 42% longer than nonobese adults (adjusted event time ratio [ETR], 1.42; 95% confidence interval [CI], 1.06-1.89); no association was observed with influenza B virus shedding duration. Even among paucisymptomatic and asymptomatic adults, obesity increased the influenza A shedding duration by 104% (adjusted ETR, 2.04; 95% CI, 1.35-3.09). These findings suggest that obesity may play an important role in influenza transmission.

引用

页码：1378 / 1382

页数：5

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