In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
机构:
Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
Sichuan Univ, West China Med Sch, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Med Sch, West China Hosp, Ctr Canc, Chengdu 610041, Sichuan, Peoples R ChinaChinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
Lu, Guangwen
Wang, Qihui
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Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
Chinese Acad Sci, Inst Microbiol, CAS Key Lab Microbial Physiol & Metab Engn, Beijing 100101, Peoples R ChinaChinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
Wang, Qihui
Gao, George F.
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Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
Chinese Ctr Dis Control & Prevent China CDC, Off Director Gen, Beijing 102206, Peoples R ChinaChinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
机构:
Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
Sichuan Univ, West China Med Sch, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Med Sch, West China Hosp, Ctr Canc, Chengdu 610041, Sichuan, Peoples R ChinaChinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
Lu, Guangwen
Wang, Qihui
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
Chinese Acad Sci, Inst Microbiol, CAS Key Lab Microbial Physiol & Metab Engn, Beijing 100101, Peoples R ChinaChinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
Wang, Qihui
Gao, George F.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
Chinese Ctr Dis Control & Prevent China CDC, Off Director Gen, Beijing 102206, Peoples R ChinaChinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China