The spike glycoprotein of the new coronavirus 2019-nCoV contains a furinlike cleavage site absent in CoV of the same clade

被引：1172

作者：

Coutard, B. ^{[1
]}

Valle, C. ^{[2
]}

de lamballerie, X. ^{[1
]}

Canard, B. ^{[2
]}

Seidah, N. G. ^{[3
]}

Decroly, E. ^{[2
]}

机构：

[1] Aix Marseille Univ, IHU Mediterranee Infect, INSERM 1207, IRD 190,UVE, Marseille, France

[2] Aix Marseille Univ, CNRS, UMR 7257, AFMB, Marseille, France

[3] Univ Montreal, IRCM, Montreal Clin Res Inst, Lab Biochem Neuroendocrinol, 110 Pine Ave West, Montreal, PQ H2W 1R7, Canada

来源：

ANTIVIRAL RESEARCH | 2020年 / 176卷

基金：

欧盟地平线“2020”;

关键词：

2019-nCoV; SARS-CoV; Spike protein; Maturation protease; Furin; Antivirals; RESPIRATORY SYNDROME CORONAVIRUS; PROPROTEIN CONVERTASES; FUNCTIONAL RECEPTOR; IN-VITRO; INFLUENZA; PROTEASES; PROTEIN; INHIBITION; ACTIVATION; EXPRESSION;

D O I：

10.1016/j.antiviral.2020.104742

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.

引用

页数：5

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