The spike glycoprotein of the new coronavirus 2019-nCoV contains a furinlike cleavage site absent in CoV of the same clade

被引：1172
作者：
Coutard, B. [1 ]
Valle, C. [2 ]
de lamballerie, X. [1 ]
Canard, B. [2 ]
Seidah, N. G. [3 ]
Decroly, E. [2 ]
机构：
[1] Aix Marseille Univ, IHU Mediterranee Infect, INSERM 1207, IRD 190,UVE, Marseille, France
[2] Aix Marseille Univ, CNRS, UMR 7257, AFMB, Marseille, France
[3] Univ Montreal, IRCM, Montreal Clin Res Inst, Lab Biochem Neuroendocrinol, 110 Pine Ave West, Montreal, PQ H2W 1R7, Canada
来源：
ANTIVIRAL RESEARCH | 2020年 / 176卷
基金：
欧盟地平线“2020”;
关键词：
2019-nCoV; SARS-CoV; Spike protein; Maturation protease; Furin; Antivirals; RESPIRATORY SYNDROME CORONAVIRUS; PROPROTEIN CONVERTASES; FUNCTIONAL RECEPTOR; IN-VITRO; INFLUENZA; PROTEASES; PROTEIN; INHIBITION; ACTIVATION; EXPRESSION;
D O I：
10.1016/j.antiviral.2020.104742
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
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页数：5
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