Role of neutrophils, platelets, and extracellular vesicles and their interactions in COVID-19-associated thrombopathy

被引：48

作者：

Caillon, Antoine ^{[1
]}

Trimaille, Antonin ^{[2
,3
]}

Favre, Julie ^{[4
,5
]}

Jesel, Laurence ^{[2
,3
]}

Morel, Olivier ^{[2
,3
]}

Kauffenstein, Gilles ^{[2
]}

机构：

[1] McGill Univ, Lady Davis Inst Med Res, Montreal, PQ, Canada

[2] Strasbourg Univ, CRBS, UMR INSERM 1260, Strasbourg, France

[3] Strasbourg Univ Hosp, Div Cardiovasc Med, Nouvel Hop Civil, Strasbourg, France

[4] CRBS, Biomat & Bioengn, INSERM, UMR S 1121, Strasbourg, France

[5] Univ Strasbourg, Fac Chirurg Dent, Strasbourg, France

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2022年 / 20卷 / 01期

关键词：

COVID-19; extracellular vesicles; neutrophils; platelets; therapeutic strategy; thrombosis; CRITICALLY-ILL PATIENTS; NECROSIS-FACTOR-ALPHA; TISSUE FACTOR; DNA TRAPS; THROMBOTIC COMPLICATIONS; VENOUS THROMBOEMBOLISM; VASCULAR HOMEOSTASIS; COVID-19; MICROPARTICLES; INTERLEUKIN-6;

D O I：

10.1111/jth.15566

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The COVID-19 pandemic extended all around the world causing millions of deaths. In addition to acute respiratory distress syndrome, many patients with severe COVID-19 develop thromboembolic complications associated to multiorgan failure and death. Here, we review evidence for the contribution of neutrophils, platelets, and extracellular vesicles (EVs) to the thromboinflammatory process in COVID-19. We discuss how the immune system, influenced by pro-inflammatory molecules, EVs, and neutrophil extracellular traps (NETs), can be caught out in patients with severe outcomes. We highlight how the deficient regulation of the innate immune system favors platelet activation and induces a vicious cycle amplifying an immunothrombogenic environment associated with platelet/NET interactions. In light of these considerations, we discuss potential therapeutic strategies underlining the modulation of purinergic signaling as an interesting target.

引用

页码：17 / 31

页数：15

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