H2AX regulates meiotic telomere clustering

被引：49

作者：

Fernandez-Capetillo, O

Liebe, B

Scherthan, H

Nussenzweig, A

机构：

[1] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA

[2] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

来源：

JOURNAL OF CELL BIOLOGY | 2003年 / 163卷 / 01期

关键词：

DNA repair; genomic instability; meiosis; ATM; spermatocyte;

D O I：

10.1083/jcb.200305124

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

T he histone H2A variant H2AX is phosphorylated in response to DNA double-strand breaks originating from diverse origins, including dysfunctional telomeres. Here, we show that normal mitotic telomere maintenance does not require H2AX. Moreover, H2AX is dispensable for the chromosome fusions arising from either critically shortened or deprotected telomeres. However, H2AX has an essential role in controlling the proper topological distribution of telomeres during meiotic prophase 1. Our results suggest that H2AX is a downstream effector of the ataxia telangiectasia-mutated kinase in controlling telomere movement during meiosis.

引用

页码：15 / 20

页数：6

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