Efficient production of oligomeric chitin with narrow distributions of degree of polymerization using sonication-assisted phosphoric acid hydrolysis

被引：16
作者：
Zhang, Xin [1 ]
Mao, Yimin [1 ,2 ]
Briber, Robert M. [1 ]
机构：
[1] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA
[2] NIST, Ctr Neutron Res, Gaithersburg, MD 20899 USA
来源：
CARBOHYDRATE POLYMERS | 2022年 / 276卷
关键词：
Chitin; Oligomer; Oligosaccharide; N-acetyl chitooligosaccharide; Acid hydrolysis; Phosphoric acid; Ultrasound; INDUCTION; DEPOLYMERIZATION; SUPPLEMENTATION; IDENTIFICATION; PERFORMANCE; ANTICANCER; EXPRESSION; RESISTANCE; FRAGMENTS; CHITOSAN;
D O I：
10.1016/j.carbpol.2021.118736
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A method of producing oligomeric chitin using sonication-assisted phosphoric acid hydrolysis was introduced. The processing was continuous and scalable. Oligomeric chitin fractions with narrow distributions of degree of polymerization were obtained by differential precipitation using ethanol as precipitating agent at different ethanol-to-phosphoric-acid-solution volume ratios. The yield of oligomeric chitin with degree of polymerization between 4 and 10 was approximate to 30% (mass fraction). The content of each fraction was characterized by matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI TOF MS). Changes in chemical composition of oligomeric chitin were negligible, as verified by MALDI TOF MS, Fourier-transform infrared, and nuclear magnetic resonance spectroscopy. This new method for producing oligomeric chitin molecules is rapid, costeffective, and safe.
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页数：6
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