X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Gastric Cancer Risk: A HuGE Review and Meta-Analysis

被引:60
作者
Xue, Huiping [2 ]
Ni, Peihua [3 ]
Lin, Bing [4 ]
Xu, Hong [5 ]
Huang, Gang [1 ]
机构
[1] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Nucl Med, Shanghai 200127, Peoples R China
[2] Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Inst Gastrointestinal Dis, Dept Gastroenterol,Sch Med, Shanghai 200127, Peoples R China
[3] Shanghai Jiao Tong Univ, Fac Lab Med, Ruijin Hosp, Sch Med, Shanghai 200127, Peoples R China
[4] Fudan Univ, Sch Med, Div Nutr, Zhongshan Hosp, Shanghai 200433, Peoples R China
[5] Shanghai Jiao Tong Univ, Div Biochem, Sch Med, Shanghai 200127, Peoples R China
基金
中国国家自然科学基金;
关键词
association; epidemiology; genetics; genome; human; polymorphism; single nucleotide; stomach neoplasms; X-ray repair cross complementing protein 1; XRCC1; BASE EXCISION-REPAIR; DNA-REPAIR; CARDIA; ADENOCARCINOMA; SUSCEPTIBILITY; ASSOCIATION; CARCINOMA; XPD;
D O I
10.1093/aje/kwq378
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The authors performed a systematic review and meta-analysis of associations of the x-ray repair cross-complementing 1 gene (XRCC1) single nucleotide polymorphisms (SNPs) Arg194Trp, Arg280His, and Arg399Gln with gastric cancer risk, based on eligible studies retrieved from electronic databases for the period January 2000-December 2009. Ultimately, 12, 6, and 3 studies were found to be eligible for meta-analyses of Arg399Gln, Arg194Trp, and Arg280His, respectively. Regrouping was adopted in accordance with the most probably appropriate genetic models. Potential sources of heterogeneity were sought out. For overall gastric cancer, the pooled odds ratios for Arg399Gln, Arg194Trp, and Arg280His were 1.04 (95% confidence interval (CI): 0.90, 1.20; P = 0.572), 0.83 (95% CI: 0.68, 1.01; P = 0.059), and 1.18 (95% CI: 0.92, 1.50; P = 0.194), respectively. After stratification of the Arg399Gln SNP data by anatomic type (cardia vs. noncardia), the pooled odds ratio was 1.07 (95% CI: 0.84, 1.37; P = 0.568). The authors conclude that the 3 SNPs evaluated are not associated with risk of gastric cancer. The Arg399Gln SNP is not associated with the cardia type of gastric cancer. Evidently, the heterogeneity regarding the Arg399Gln SNP across studies is not explained by ethnicity, genotyping technique, sample size, or date of publication.
引用
收藏
页码:363 / 375
页数:13
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