RETINAL VASCULAR PLEXUSES' CHANGES IN DRY AGE-RELATED MACULAR DEGENERATION, EVALUATED BY MEANS OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

被引:0
作者
Toto, Lisa [1 ]
Borrelli, Enrico [1 ]
Di Antonio, Luca [1 ]
Carpineto, Paolo [1 ]
Mastropasqua, Rodolfo [2 ]
机构
[1] Univ G dAnnunzio, Dept Med & Sci Ageing, Ophthalmol Clin, Chieti, Italy
[2] Univ Verona, Dept Neurol Neuropsychol Morphol & Movement Sci, Ophthalmol Unit, Verona, Italy
来源
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2016年 / 36卷 / 08期
关键词
age-related macular degeneration; AMD; choroid; choroidal thickness; optical coherence tomography angiography; retinal vessel; vessel density; SOURCE OCT ANGIOGRAPHY; CHOROIDAL THICKNESS; BLOOD-FLOW; MACULOPATHY; EYES; PROGRESSION; AMD;
D O I
暂无
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To investigate alteration in superficial and deep retinal vascular densities and choroidal thickness, in patients affected by early and intermediate age-related macular degeneration (AMD). Methods: All patients had undergone optical coherence tomography angiography (OCTA). All eyes were grouped into two stages: "early AMD" and "intermediate AMD." Outcome measures were superficial vessel density, deep vessel density, and choroidal thickness. A control group of healthy subjects was selected for the statistical comparisons. Results: A total of 37 eyes of 37 dry AMD patients were enrolled for the study. Fourteen of 37 eyes were classified as having early AMD, the remaining 23 of 37 eyes were classified as being affected by intermediate AMD. Superficial and deep vessel densities were 39.21% +/- 10.67% and 43.84% +/- 11.57%, respectively, in the control group and 28.30% +/- 10.73% and 36.41% +/- 12.30%, respectively, in AMD patients (P = 0.001 and P = 0.017, respectively). Choroidal thickness was significantly reduced in AMD patients. Conclusion: In the last years, several studies have reported vascular factors playing an important role in AMD pathogenesis. We demonstrated that both superficial and deep retinal plexuses are altered among patients affected by AMD. Interestingly, this alteration starts immediately at the intermediate AMD stage and also the choroidal thickness reduction.
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页码:1566 / 1572
页数:7
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