MODOMICS: a database of RNA modification pathways. 2017 update

被引：1394

作者：

Boccaletto, Pietro ^{[1
]}

Machnicka, Magdalena A. ^{[1
,2
]}

Purta, Elzbieta ^{[1
]}

Piatkowski, Pawe ^{[1
]}

Baginski, Blazej ^{[1
]}

Wirecki, Tomasz K. ^{[1
]}

de Crecy-Lagard, Valerie ^{[3
]}

Ross, Robert ^{[4
]}

Limbach, Patrick A. ^{[4
]}

Kotter, Annika ^{[5
]}

Helm, Mark ^{[5
]}

Bujnicki, Janusz M. ^{[1
,6
]}

机构：

[1] Int Inst Mol & Cell Biol Warsaw, Lab Bioinformat & Prot Engn, Ul Ks Trojdena 4, PL-02109 Warsaw, Poland

[2] Univ Warsaw, Inst Informat, Banacha 2, PL-02097 Warsaw, Poland

[3] Univ Florida, Microbiol & Cell Sci Dept, Gainesville, FL 32611 USA

[4] Univ Cincinnati, Rieveschl Labs Mass Spectrometry, Dept Chem, Cincinnati, OH 45221 USA

[5] Johannes Gutenberg Univ Mainz, Inst Pharm & Biochim, Staudinger Weg 5, D-55128 Mainz, Germany

[6] Adam Mickiewicz Univ, Fac Biol, Ul Umultowska 89, PL-61614 Poznan, Poland

来源：

NUCLEIC ACIDS RESEARCH | 2018年 / 46卷 / D1期

基金：

美国国家卫生研究院;

关键词：

POSTTRANSCRIPTIONAL MODIFICATIONS; RIBOSOMAL-RNA; IDENTIFICATION; MITOCHONDRIAL; LANDSCAPE; BIOGENESIS; GENERATION; ANTICODON; POSITION;

D O I：

10.1093/nar/gkx1030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MODOMICS is a database of RNA modifications that provides comprehensive information concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways, the location of modified residues in RNA sequences, and RNA-modifying enzymes. In the current database version, we included the following new features and data: extended mass spectrometry and liquid chromatography data for modified nucleosides; links between human tRNA sequences and MINTbase - a framework for the interactive exploration of mitochondrial and nuclear tRNA fragments; new, machine-friendly system of unified abbreviations for modified nucleoside names; sets of modified tRNA sequences for two bacterial species, updated collection of mammalian tRNA modifications, 19 newly identified modified ribonucleosides and 66 functionally characterized proteins involved in RNA modification. Data from MODOMICS have been linked to the RNAcentral database of RNA sequences. MODOMICS is available at http://modomics.genesilico.pl.

引用

页码：D303 / D307

页数：5

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