Aging influence on functional connectivity of the motor network in the resting state

被引：77
作者：
Wu, Tao
Zang, Yufeng
Wang, Liang
Long, Xiangyu
Hallett, Mark
Chen, Yi
Li, Kuncheng
Chan, Piu
机构：
[1] Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing Inst Geriatr, Beijing 100053, Peoples R China
[2] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
[3] Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
[4] NINDS, Human Motor Control Sect, Med Neurol Branch, NIH, Bethesda, MD 20892 USA
来源：
NEUROSCIENCE LETTERS | 2007年 / 422卷 / 03期
基金：
中国国家自然科学基金;
关键词：
aging; functional connectivity; motor network; resting state;
D O I：
10.1016/j.neulet.2007.06.011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We used functional MRI (fMRI) to study the aging influence on functional connectivity of the motor network in the resting state. A network model based on graph theory was used to measure functional connectivity. The total connectivity degree of each region within the motor network was calculated and compared between aged and young groups. We found that the pattern of functional connectivity was changed in aged subjects, including a significant decrease in the functional connectivity degree of the right cingulate motor area and left premotor area compared to young subjects. Our study demonstrates that normal aging modulates the functional connectivity of motor network in the resting state. We postulate that this abnormal functional connectivity of motor network in the baseline state is an important reason contributing to the deteriorated motor ability in aged subjects. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：164 / 168
页数：5
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