Update on the Treatment of Pulmonary Arterial Hypertension

被引：11

作者：

Fernandes, Caio J. ^{[1
,2
,3
]}

Calderaro, Daniela ^{[1
,4
]}

Luppino Assad, Ana Paula ^{[1
,3
,5
]}

Salibe-Filho, William ^{[1
]}

Kato-Morinaga, Luciana Tamie ^{[1
,3
]}

Hoette, Susana ^{[1
,3
]}

Piloto, Bruna ^{[1
,3
]}

Castro, Marcela Araujo ^{[1
,3
]}

Lisboa, Roberta Pontes ^{[1
,3
]}

Felix da Silva, Taysa Antonia ^{[1
]}

Martins, Murillo de Araujo ^{[1
,2
,3
]}

Alves-Jr, Jose L. ^{[1
,3
]}

Jardim, Carlos ^{[1
,3
]}

Terra-Filho, Mario ^{[1
,3
]}

de Souza, Rogerio ^{[1
,3
]}

机构：

[1] Univ Sao Paulo, Fac Med, Div Pneumol Incor, Unidade Circulacao Pulm, Av Dr Eneas Carvalho Aguiar 44, BR-05403000 Sao Paulo, SP, Brazil

[2] Univ Sao Paulo, Inst Canc, Fac Med, Sao Paulo, SP, Brazil

[3] Hosp Sirio Libanes, Sao Paulo, SP, Brazil

[4] Univ Sao Paulo, Fac Med, Div Cardiol Incor, Unidade Med Interdisciplinar, Sao Paulo, SP, Brazil

[5] Univ Sao Paulo, Fac Med, Hosp Clin, Disciplina Reumatol, Sao Paulo, SP, Brazil

来源：

ARQUIVOS BRASILEIROS DE CARDIOLOGIA | 2021年 / 117卷 / 04期

关键词：

Pulmonary Arterial Hypertension; Pulmonary Hypertension; Diagnosis; Therapeutics; MAIN CORONARY-ARTERY; CONNECTIVE-TISSUE DISEASES; CALCIUM-CHANNEL BLOCKERS; PORTOPULMONARY HYPERTENSION; COMBINATION THERAPY; SYSTEMIC-SCLEROSIS; EPOPROSTENOL PROSTACYCLIN; IMMUNOSUPPRESSIVE THERAPY; EXTRINSIC COMPRESSION; EISENMENGER-SYNDROME;

D O I：

10.36660/abc.20200702

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the last decades, important advances have been made in the treatment of pulmonary arterial hypertension (PAH), a severe, progressive, incurable, and potentially fatal disease. For an adequate therapy, correct hemodynamic diagnosis and etiology classification are fundamental. Many etiologies - rheumatic disease, portal hypertension, congenital heart diseases, schistosomiasis - require specific measures, in addition to drug therapy for PAH. The specific therapy for PAH is based on medications that act on three pathophysiological pathways - prostacyclin, endothelin, and nitric oxide pathways. These drugs have multiple presentations (oral, intravenous, subcutaneous, and inhaled) and have changed the history of PAH. This review presents an overview of drug therapy strategies and different forms and peculiarities of PAH.

引用

收藏

页码：750 / 763

页数：14

相关论文

共 121 条

[1] Epoprostenol (prostacyclin) therapy in HIV-associated pulmonary hypertension [J].

Aguilar, RV ;

Farber, HW .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (05) :1846-1850

[2] Pulmonary hypertension in connective tissue diseases: an update [J].

Aithala, Ramya ;

Alex, Anoop G. ;

Danda, Debashish .

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2017, 20 (01) :5-24

[3] Prognostic relevance of appropriate renal function evaluation in pulmonary arterial hypertension [J].

Alves-, Jose Leonidas, Jr. ;

Souza, Rogerio .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2018, 37 (06) :692-693

[4] Pulmonary Hypertension: Definition, Classification, and Diagnosis [J].

Alves-, Jose Leonidas, Jr. ;

Oleas, Francisca Gavilanes ;

Souza, Rogerio .

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 38 (05) :561-570

[5] Pulmonary Arterial Hypertension in the Southern Hemisphere Results From a Registry of Incident Brazilian Cases [J].

Alves, Jose Leonidas, Jr. ;

Gavilanes, Francisca ;

Jardim, Carlos ;

Cesar dos Santos Fernandes, Caio Julio ;

Kato Morinaga, Luciana Tamie ;

Dias, Bruno ;

Hoette, Susana ;

Humbert, Marc ;

Souza, Rogerio .

CHEST, 2015, 147 (02) :495-501

[6] Prevalence of Pulmonary Hypertension in Systemic Sclerosis in European Caucasians and Metaanalysis of 5 Studies [J].

Avouac, Jerome ;

Airo, Paulo ;

Meune, Christophe ;

Beretta, Lorenzo ;

Dieude, Philippe ;

Caramaschi, Paola ;

Tiev, Kiet ;

Cappelli, Susanna ;

Diot, Elisabeth ;

Vacca, Alessandra ;

Cracowski, Jean-Luc ;

Sibilia, Jean ;

Kahan, Andre ;

Matucci-Cerinic, Marco ;

Allanore, Yannick .

JOURNAL OF RHEUMATOLOGY, 2010, 37 (11) :2290-2298

[7] Pulmonary Arterial Hypertension Baseline Characteristics From the REVEAL Registry [J].

Badesch, David B. ;

Raskob, Gary E. ;

Elliott, C. Greg ;

Krichman, Abby M. ;

Farber, Harrison W. ;

Frost, Adaani E. ;

Barst, Robyn. J. ;

Benza, Raymond L. ;

Liou, Theodore G. ;

Turner, Michelle ;

Giles, Scott ;

Feldkircher, Kathy ;

Miller, Dave P. ;

McGoon, Michael D. .

CHEST, 2010, 137 (02) :376-387

[8] A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension [J].

Barst, RJ ;

Rubin, LJ ;

Long, WA ;

McGoon, MD ;

Rich, S ;

Badesch, DB ;

Groves, BM ;

Tapson, VF ;

Bourge, RC ;

Brundage, BH ;

Koerner, SK ;

Langleben, D ;

Keller, CA ;

Murali, S ;

Uretsky, BF ;

Clayton, LM ;

Jobsis, MM ;

Blackburn, SD ;

Shortino, D ;

Crow, JW .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (05) :296-301

[9] Eisenmenger Syndrome A Clinical Perspective in a New Therapeutic Era of Pulmonary Arterial Hypertension [J].

Beghetti, Maurice ;

Galie, Nazzareno .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 53 (09) :733-740

[10] Predicting Survival in Patients With Pulmonary Arterial Hypertension The REVEAL Risk Score Calculator 2.0 and Comparison With ESC/ERS-Based Risk Assessment Strategies [J].

Benza, Raymond L. ;

Gomberg-Maitland, Mardi ;

Elliott, C. Greg ;

Farber, Harrison W. ;

Foreman, Aimee J. ;

Frost, Adaani E. ;

McGoon, Michael D. ;

Pasta, David J. ;

Selej, Mona ;

Burger, Charles D. ;

Frantz, Robert P. .

CHEST, 2019, 156 (02) :323-337

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