A Biomimetic Material with a High Bio-responsibility for Bone Reconstruction and Tissue Engineering

被引：9
作者：
Chen, Xiaofeng [1 ,2 ]
Meng, Yongchun [1 ,2 ]
Wang, Yingjun [1 ,2 ]
Du, Chang [1 ,2 ]
Yang, Chunrong [1 ,2 ]
机构：
[1] S China Univ Technol, Coll Mat Sci & Engn, Biomat Res Inst, Guangzhou 510640, Guangdong, Peoples R China
[2] S China Univ Technol, Minist Educ, Key Lab Specially Funct Mat, Guangzhou 510640, Guangdong, Peoples R China
来源：
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2011年 / 22卷 / 1-3期
基金：
中国国家自然科学基金;
关键词：
Bioactive glass; collagen; bio-mineralization; biomimetic; bone reconstruction; IN-VITRO; BIOACTIVE GLASSES; COLLAGEN-FIBERS; APATITE LAYER; ACID; HYDROXYAPATITE; SCAFFOLDS; ORGANIZATION; COMPOSITES; BEHAVIOR;
D O I：
10.1163/092050609X12583524936191
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A biomimetic composite was prepared using type-I collagen as the matrix, and particles of sol-gel-derived bioactive glass (58S), hyaluronic acid and phosphatidylserine as additives. The material has an interconnected 3-D porous structure with a porosity > 85%. When incubated in simulated body fluid (SBF), the composite induced the formation of microcrystals of bone-like hydroxyapatite (HA), suggesting good bioactive properties. During the in vitro cell-culture experiment, MC3T3-E1 cells adhered to, migrated and spread on the surface of the porous composite. The material was employed to repair a 10-mm defect in a rabbit's radius. The composite was gradually degraded within 8 weeks and replaced by new bone. After 12 weeks, the bone marrow cavity was restored and the Haversian canal was noted from the histological observation. The biomimetic composite is a potential scaffold material for bone reconstruction and bone tissue engineering. (C) Koninklijke Brill NV, Leiden, 2011
引用
收藏
页码：153 / 163
页数：11
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