LncRNA HOXA-AS2 and its molecular mechanisms in human cancer

被引：228

作者：

Wang, Jicai ^{[1
]}

Su, Zhilei ^{[1
]}

Lu, Shounan ^{[1
]}

Fu, Wen ^{[1
]}

Liu, Zhifa ^{[1
]}

Jiang, Xingming ^{[1
]}

Tai, Sheng ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 2, Dept Hepatopancreatobiliary Surg, 246 XueFu Ave, Harbin 150086, Heilongjiang, Peoples R China

来源：

CLINICA CHIMICA ACTA | 2018年 / 485卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

IncRNA; HOXA-AS2; Diagnosis; Therapeutic target; Prognosis; LONG NONCODING RNA; EPITHELIAL-MESENCHYMAL TRANSITION; ANTISENSE LINCRNA HOXA-AS2; GASTRIC-CANCER; CELL-PROLIFERATION; COLORECTAL-CANCER; TUMOR-SUPPRESSOR; DNA METHYLATION; EXPRESSION; STATISTICS;

D O I：

10.1016/j.cca.2018.07.004

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Long non-coding RNAs (lncRNAs), a novel class of noncoding RNAs, are commonly defined as RNA molecules more than 200 nucleotides in length. Emerging research indicated that lncRNA played a vital role in human tumorigenesis and progression by serving as tumor oncogenes or suppressors. LncRNA has been shown to get involved in participate various biological processes, such as cell growth, anti-apoptosis, migration and invasion. LncRNA HOXA cluster antisense RNA2 (HOXA-AS2) is a novel cancer-related lncRNA. It was recently found to exhibit aberrant expression in a variety of malignancies, including breast cancer, gastric cancer, gallbladder carcinoma, hepatocellular carcinoma and pancreatic cancer. The oncogenicity of lncRNA HOXA-AS2 mainly inhibits or promotes the expression of related genes through direct or indirect pathways, suggesting that HOXA-AS2 likely represents a feasible biomarker or therapeutic target in human cancers. In this review, we summarize current evidences concerning the biological functions and mechanisms of HOXA-AS2 during tumor development.

引用

页码：229 / 233

页数：5

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