Extent and characteristics of immune infiltration in clear cell renal cell carcinoma and the prognostic value

被引：22
作者：
Wang, Yuhao [1 ]
Yang, Jie [1 ]
Zhang, Qijie [1 ]
Xia, Jiadong [1 ]
Wang, Zengjun [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Urol, Nanjing 210029, Jiangsu, Peoples R China
来源：
TRANSLATIONAL ANDROLOGY AND UROLOGY | 2019年 / 8卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Clear cell renal cell carcinoma (ccRCC); immune infiltration; T-reg; TCGA; prognosis; REGULATORY T-CELLS; CANCER; IMMUNOSUPPRESSION; HETEROGENEITY;
D O I：
10.21037/tau.2019.10.19
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
Background: Immune infiltration has an important impact on the development of clear cell renal cell carcinoma (ccRCC). This article aims to investigate the association between immune infiltration and the clinical features as well as prognosis of clear cell renal cell carcinoma. Methods: Analyze the immune infiltration in ccRCC by applying ESTIMATE and CIBERSORT methods on basic of dataset in TCGA and GEO. And identify the kind of immune cell and genes that may play the central role. Results: High Immune score and high property of T-regs are both significantly associated with the poor OS, high stage and more chances of metastases in ccRCC. CXCL-1, SAA1, PMCH, CCL-5 are all significantly negatively correlated to OS and positively correlated to stage and chance of metastases in ccRCC. High property of T- regs, CXCL-1 and SAA1 are also significantly associated with high Fuhrman grade while PMCH and CCL5 not. Conclusions: Immune infiltration in RCC has a negative influence on ccRCC and T-regs may play a vital role in this process mediated by CXCL-1 or SSA1.
引用
收藏
页码：609 / 618
页数：10
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