Association between selective IgA deficiency and COVID-19

被引:29
作者
Naito, Yuji [1 ]
Takagi, Tomohisa [1 ]
Yamamoto, Tetsuro [2 ]
Watanabe, Shaw [3 ]
机构
[1] Kyoto Prefectural Univ Med, Dept Gastroenterol & Hepatol, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028066, Japan
[2] TTC Co Ltd, Sibuya Ku, 1-20-2 Ebisu Nishi, Tokyo 1500021, Japan
[3] Life Sci Promoting Assoc, Asia Pacific Clin Nutr Soc, Shinjuku Ku, 25-3-1004 Daijyo Cho, Tokyo 1600015, Japan
关键词
COVID-19; IgA deficiency; mortality;
D O I
10.3164/jcbn.20-102
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The purpose of this study was to propose a hypothesis that there is a potential association between the incidence of selective IgA deficiency in various countries and COVID-19 cases. The number of deaths due to COVID-19 increased in clear proportion to the number of infected patients, and the difference in the number of deaths by country was due to the difference in the number of infected patients. The frequency of selective IgA deficiency has a strong positive correlation with the prevalence of COVID-19 per population. The low infection rate contributed to the low death rate from COVID-19 in Japan, suggesting that the extremely low frequency of selective IgA deficiency may be a contributing factor.
引用
收藏
页码:122 / 125
页数:4
相关论文
共 13 条
[1]   Sustainable health promotion for the seniors during COVID-19 outbreak: a lesson from Tokyo [J].
Aung, Myo Nyein ;
Yuasa, Motoyuki ;
Koyanagi, Yuka ;
Aung, Thin Nyein Nyein ;
Moolphate, Saiyud ;
Matsumoto, Hiromichi ;
Yoshioka, Takashi .
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2020, 14 (04) :328-331
[2]   Physiology of IgA and IgA deficiency [J].
Cunningham-Rundles, C .
JOURNAL OF CLINICAL IMMUNOLOGY, 2001, 21 (05) :303-309
[3]   Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID) [J].
Hammarström, L ;
Vorechovsky, I ;
Webster, D .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2000, 120 (02) :225-231
[4]   Mucosal Immunization and Adjuvants [J].
Hasegawa, Hideki ;
van Reit, Elly ;
Kida, Hiroshi .
INFLUENZA PATHOGENESIS AND CONTROL - VOL II, 2015, 386 :371-380
[5]   SELECTIVE IGA DEFICIENCY IN JAPANESE BLOOD-DONORS - FREQUENCY AND STATISTICAL-ANALYSIS [J].
KANOH, T ;
MIZUMOTO, T ;
YASUDA, N ;
KOYA, M ;
OHNO, Y ;
UCHINO, H ;
YOSHIMURA, K ;
OHKUBO, Y ;
YAMAGUCHI, H .
VOX SANGUINIS, 1986, 50 (02) :81-86
[6]   The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency [J].
Odineal, David D. ;
Gershwin, M. Eric .
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2020, 58 (01) :107-133
[7]   IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody [J].
Saito, Shinji ;
Sano, Kaori ;
Suzuki, Tadaki ;
Ainai, Akira ;
Taga, Yuki ;
Ueno, Tomonori ;
Tabata, Koshiro ;
Saito, Kumpei ;
Wada, Yuji ;
Ohara, Yuki ;
Takeyama, Haruko ;
Odagiri, Takato ;
Kageyama, Tsutomu ;
Ogawa-Goto, Kiyoko ;
Multihartina, Pretty ;
Setiawaty, Vivi ;
Pangesti, Krisna Nur Andriana ;
Hasegawa, Hideki .
PLOS PATHOGENS, 2019, 15 (01)
[8]  
Samant H., 2020, STATPEARLS
[9]  
Watanabe S., 2020, INT J FAM MED PRIM C, V1, P1011, DOI [10.25107/IJFMPC-v1-id1011, DOI 10.25107/IJFMPC-V1-ID1011]
[10]   Effect of ingesting yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on influenza virus-bound salivary IgA in elderly residents of nursing homes: a randomized controlled trial [J].
Yamamoto, Yuko ;
Saruta, Jun ;
Takahashi, Toru ;
To, Masahiro ;
Shimizu, Tomoko ;
Hayashi, Takashi ;
Morozumi, Toshiya ;
Kubota, Nobuhisa ;
Kamata, Yohei ;
Makino, Seiya ;
Kano, Hiroshi ;
Hemmi, Jun ;
Asami, Yukio ;
Nagai, Takayuki ;
Misawa, Kyoko ;
Kato, Sachiko ;
Tsukinoki, Keiichi .
ACTA ODONTOLOGICA SCANDINAVICA, 2019, 77 (07) :517-524