The preparation of acrylamide modified carbon paste electrode and its electrocatalytic oxidation to dopamine (DA) in 0.2 M phosphate buffer (PBS) at 7.4 pH were presented. Several parameters such as DA concentration, scan rate variation and pH were investigated by the cyclic voltammetric technique (CV). The peak currents were proportional to the concentration of DA with a detection limit of 3.5x10(-7) M. The concentration effect of modifier in the carbon paste electrode also reveals that the change in the electrode interface which would lead to the formation of anionic charge on the surface of the electrode could enhance the cationic charged dopamine. The stability and repeatability of the electrode for the determination of DA were also investigated.