Circulating Tumor Cells: Detection Methods and Potential Clinical Application in Breast Cancer

被引：18
作者：
Kim, Seung Il [1 ]
Jung, Hyo-il [2 ]
机构：
[1] Yonsei Univ, Coll Med, Dept Surg, Seoul 120752, South Korea
[2] Yonsei Univ, Sch Mech Engn, Seoul 120752, South Korea
来源：
JOURNAL OF BREAST CANCER | 2010年 / 13卷 / 02期
关键词：
Breast neoplasms; Circulating neoplastic cells; Clinical application; Detection; POLYMERASE-CHAIN-REACTION; RNA-POSITIVE CELLS; PERIPHERAL-BLOOD; BONE-MARROW; ADJUVANT CHEMOTHERAPY; DISEASE PROGRESSION; MOLECULAR-DETECTION; PROGNOSTIC VALUE; EARLY RELAPSE; HER2; STATUS;
D O I：
10.4048/jbc.2010.13.2.125
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Circulating tumor cells (CTCs) are defined as tumor cells circulating in the peripheral blood of patients. CTCs have long been regarded as an attractive research topic. Because of recent technological advances, it is now possible to detect CTCs in the bloodstream. Interestingly, CTCs are present in both of patients with metastatic disease and early stage localized disease in patients with breast cancer. An assay detecting CTCs seems to have significant future potential value in the clinical management of breast cancer as a prognostic marker, monitoring treatment response and selecting target therapy. This review addresses the technical overview of detection methods, possible clinical application and future direction of CTCs research.
引用
收藏
页码：125 / 131
页数：7
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