Lack of monomeric IgM anti-hepatitis C virus (HCV) core antibodies in patients with chronic HCV infection

被引:6
作者
Negro, F
Troonen, H
Michel, G
Giostra, E
Albrecht, M
Perrin, L
Hadengue, A
机构
[1] ABBOTT DIAGNOST GMBH,D-55205 WIESBADEN,GERMANY
[2] UNIV GENEVA,HOP CANTONAL,VIROL LAB,CH-1211 GENEVA 14,SWITZERLAND
关键词
hepatitis C virus; IgM anti-core; chronic hepatitis;
D O I
10.1016/0166-0934(96)02058-7
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Antibodies of the IgM class against the hepatitis C virus core antigen are found in up to 70% of patients with either acute or chronic hepatitis C. The sedimentation rate of such IgM was analyzed by rate-zonal centrifugation of nine sera taken from seven patients, two acutely and five persistently infected with hepatitis C virus. All patients had circulating high-molecular weight (i.e. pentameric) IgM, indicating that the production of low molecular weight IgM, commonly observed in other persistent viral infections, does not apply to hepatitis C virus and cannot be used to distinguish acute from chronic hepatitis C virus infection.
引用
收藏
页码:179 / 182
页数:4
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