Correlation between polymorphisms in the estrogen receptor α gene and coronary heart disease: A meta-analysis

The aim of this study was to conduct a systematic evaluation the correlation between polymorphisms in the estrogen receptor alpha gene (ESR alpha) and coronary heart disease susceptibility. Case-control studies until August 2015 analyzing the correlation between the ESR alpha PvuII T/C polymorphism and coronary heart disease were obtained from various electronic databases (CBM, CNKI, Wanfang Data, VIP, and MEDLINE, Cochrane Library, Embase, Springer, and Ovid. The data obtained from these studies were evaluated and valid data was extracted. A meta-analysis was performed using RevMan 5.0. Eleven cases, comprising 1742 patients with coronary heart disease and 2012 controls, that conformed to the inclusion criteria set in this study were extracted. The results of our meta-analysis indicated that the C and T alleles, the TC+CC and TT genotypes, and the CC and TT+TC genotypes did not differ significantly. The results of this meta-analysis confirmed that there was no correlation between polymorphisms in ESR alpha and coronary heart disease susceptibility in the Chinese population.