Enantioselective Synthesis of Tetrahydropyrano[3,4-b]indoles Catalyzed by Chiral N-Triflyl Phosphoramide via Intramolecular Friedel-Crafts Alkylation Reaction

被引：20
作者：
Zhang, Jun-Wei [1 ,2 ]
Cai, Quan [2 ]
Shi, Xiao-Xin [1 ]
Zhang, Wei [2 ]
You, Shu-Li [1 ,2 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
SYNLETT | 2011年 / 09期
关键词：
asymmetric catalysis; chiral Bronsted acids; N-triflyl phosphoramide; Friedel-Crafts; indoles; BRONSTED ACID; INDOLES; 4,7-DIHYDROINDOLES; HYDROARYLATION; MOTIF; DERIVATIVES; IMINES; ROUTE;
D O I：
10.1055/s-0030-1260537
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient intramolecular enantioselective Friedel-Crafts alkylation reaction of indolyl enones utilizing chiral N-triflyl phosphoramide catalyst is described. Various tetrahydropyrano[3,4-b]indoles (THPI) have been afforded with excellent yields and up to 98% ee.
引用
收藏
页码：1239 / 1242
页数：4
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