Sflt-1 in heart failure: relation with disease severity and biomarkers

被引：15

作者：

Gruson, Damien ^{[1
,2
,3
]}

Hermans, Michel P. ^{[1
,2
]}

Ferracin, Benjamin ^{[1
,2
]}

Ahn, Sylvie A. ^{[4
,5
]}

Rousseau, Michel F. ^{[4
,5
]}

机构：

[1] Clin Univ St Luc, Inst Rech Expt & Clin, Pole Rech Endocrinol Diabet & Nutr, Brussels, Belgium

[2] Catholic Univ Louvain, Brussels, Belgium

[3] Clin Univ St Luc, Dept Lab Med, Brussels, Belgium

[4] Clin Univ St Luc, Div Cardiol, Brussels, Belgium

[5] Catholic Univ Louvain, Inst Rech Expt & Clin, Pole Rech Cardiovasc, Brussels, Belgium

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 2016年 / 76卷 / 05期

关键词：

Aldosterone; BNP; Galectin-3; heart failure; prognosis sFlt-1; ST2; PLACENTAL GROWTH-FACTOR; TYROSINE KINASE 1; ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY-DISEASE; MINERALOCORTICOID RECEPTORS; CARDIAC INFLAMMATION; ADVERSE OUTCOMES; RISK; PREECLAMPSIA; ASSOCIATION;

D O I：

10.1080/00365513.2016.1190863

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Soluble fms-like tyrosine kinase-1 (sFlt-1) is an endogenous inhibitor of endothelial growth factors, such as placental growth factor (PlGF), which modulates cardiovascular (CV) remodeling. We determine sFlt-1 levels in patients with heart failure (HF) and its relationship to adverse cardiovascular (CV) events and biomarkers of cardiovascular risk. Levels of sFlt-1 and PlGF levels were also determined in healthy volunteers and patients with type 2 diabetes mellitus (T2DM). SFlt-1 and PlGF were clearly increased in HF patients in comparison to T2DM patients or healthy subjects (p<0.01). Concentration of sFlt-1 was related to HF severity (p<0.001) and was correlated to NT-proBNP (=0.37, p<0.01), soluble ST2 (=0.52, p<0.01), Galectin-3 (=0.38, p<0.01), aldosterone (=0.25, p=0.01) and PTH(1-84) (=0.38, p<0.01). Furthermore, sFlt-1 levels were associated to long-term CV risk. These results suggest a potential role of sFlt-1 in HF and its potential role as biomarker of CV risk.

引用

页码：411 / 416

页数：6

共 27 条

[1] Placental Growth Factor as a Protective Paracrine Effector in the Heart [J].

Accornero, Federica ;

Molkentin, Jeffery D. .

TRENDS IN CARDIOVASCULAR MEDICINE, 2011, 21 (08) :220-224

[2] Placental Growth Factor Regulates Cardiac Adaptation and Hypertrophy Through a Paracrine Mechanism [J].

Accornero, Federica ;

van Berlo, Jop H. ;

Benard, Matthew J. ;

Lorenz, John N. ;

Carmeliet, Peter ;

Molkentin, Jeffery D. .

CIRCULATION RESEARCH, 2011, 109 (03) :272-U95

[3] Diagnosis of preeclampsia with soluble Fms-like tyrosine kinase 1/placental growth factor ratio: an inter-assay comparison [J].

Andersen, Louise Bjorkholt ;

Frederiksen-Moller, Britta ;

Havelund, Kathrine Work ;

Dechend, Ralf ;

Jorgensen, Jan Stener ;

Jensen, Boye L. ;

Nielsen, Jan ;

Lykkedegn, Sine ;

Barington, Torben ;

Christesen, Henrik Thybo .

JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, 2015, 9 (02) :86-96

[4] Galectin-3 Mediates Aldosterone-Induced Vascular Fibrosis [J].

Calvier, Laurent ;

Miana, Maria ;

Reboul, Pascal ;

Cachofeiro, Victoria ;

Martinez-Martinez, Ernesto ;

de Boer, Rudolf A. ;

Poirier, Francoise ;

Lacolley, Patrick ;

Zannad, Faiez ;

Rossignol, Patrick ;

Lopez-Andres, Natalia .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2013, 33 (01) :67-+

[5] Placental Growth Factor and Cardiac Inflammation [J].

Carnevale, Daniela ;

Lembo, Giuseppe .

TRENDS IN CARDIOVASCULAR MEDICINE, 2012, 22 (08) :209-212

[6] Placental Growth Factor Regulates Cardiac Inflammation Through the Tissue Inhibitor of Metalloproteinases-3/Tumor Necrosis Factor-α-Converting Enzyme Axis Crucial Role for Adaptive Cardiac Remodeling During Cardiac Pressure Overload [J].

Carnevale, Daniela ;

Cifelli, Giuseppe ;

Mascio, Giada ;

Madonna, Michele ;

Sbroggio, Mauro ;

Perrino, Cinzia ;

Persico, Maria Grazia ;

Frati, Giacomo ;

Lembo, Giuseppe .

CIRCULATION, 2011, 124 (12) :1337-U123

[7] Impact of soluble fms-like tyrosine kinase-1 and placental growth factor serum levels for risk stratification and early diagnosis in patients with suspected acute myocardial infarction [J].

Hochholzer, Willibald ;

Reichlin, Tobias ;

Stelzig, Claudia ;

Hochholzer, Kirsten ;

Meissner, Julia ;

Breidthardt, Tobias ;

Reiter, Miriam ;

Duehsler, Bettina ;

Freidank, Heike ;

Winkler, Katrin ;

Twerenbold, Raphael ;

Mueller, Christian .

EUROPEAN HEART JOURNAL, 2011, 32 (03) :326-335

[8] Additive clinical value of serum brain-derived neurotrophic factor for prediction of chronic heart failure outcome [J].

Kadowaki, Shinpei ;

Shishido, Tetsuro ;

Honda, Yuki ;

Narumi, Taro ;

Otaki, Yoichiro ;

Kinoshita, Daisuke ;

Nishiyama, Satoshi ;

Takahashi, Hiroki ;

Arimoto, Takanori ;

Miyamoto, Takuya ;

Watanabe, Tetsu ;

Kubota, Isao .

HEART AND VESSELS, 2016, 31 (04) :535-544

[9] Soluble Fms-like Tyrosine Kinase 1 Is a Novel Predictor of Brain Natriuretic Peptide Elevation Results of a 5-year Observational Study Involving Japanese Patients With Coronary Artery Disease [J].

Kameda, Ryo ;

Yamaoka-Tojo, Minako ;

Makino, Akihiro ;

Wakaume, Kazuki ;

Nemoto, Shinji ;

Kitasato, Lisa ;

Shimohama, Takao ;

Tojo, Taiki ;

Machida, Yoji ;

Izumi, Tohru .

INTERNATIONAL HEART JOURNAL, 2013, 54 (03) :133-139

[10] Atorvastatin increases plasma soluble Fms-like tyrosine kinase-1 and decreases vascular endothelial growth factor and placental growth factor in association with improvement of ventricular function in acute myocardial infarction [J].

Kodama, Yasushi ;

Kitta, Yoshinobu ;

Nakamura, Takamitsu ;

Takano, Hajime ;

Umetani, Ken ;

Fujioka, Daisuke ;

Saito, Yukio ;

Kawabata, Ken-ichi ;

Obata, Jyun-ei ;

Mende, Akira ;

Kobayashi, Tsuyoshi ;

Kugiyama, Kiyotaka .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (01) :43-50

← 1 2 3 →